Evidence map›Paper›PMID 24789550›Full record

ReviewClinical journal of the American Society of Nephrology : CJASN2014

Homeostasis, the milieu intérieur, and the wisdom of the nephron.

Melanie P Hoenig, Mark L Zeidel

Abstract readReview
In one paragraph

Review in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. Dataset of xenobiotics human renal clearance values.Database : the journal of biological databases and curation · 2026
    Article
  3. Article
  4. Glycosylation in kidney diseases.Precision clinical medicine · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. The Integral Role of Chloride & With-No-Lysine Kinases in Cell Volume Regulation & Hypertension.International journal of nephrology and renovascular disease · 2023
    Review
  17. O-GlcNAcylation in Renal (Patho)Physiology.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Melanie P HoenigDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts MHoenig@bidmc.harvard.edu.
Mark L ZeidelDivision of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of homeostasis has been inextricably linked to the function of the kidneys for more than a century when it was recognized that the kidneys had the ability to maintain the "internal milieu" and allow organisms the "physiologic freedom" to move into varying environments and take in varying diets and fluids. Early ingenious, albeit rudimentary, experiments unlocked a wealth of secrets on the mechanisms involved in the formation of urine and renal handling of the gamut of electrolytes, as well as that of water, acid, and protein. Recent scientific advances have confirmed these prescient postulates such that the modern clinician is the beneficiary of a rich understanding of the nephron and the kidney's critical role in homeostasis down to the molecular level. This review summarizes those early achievements and provides a framework and introduction for the new CJASN series on renal physiology.

Indexed as

Glomerular Filtration RateRenal ReabsorptionAcid-Base EquilibriumAnimalsHumansHydrogen-Ion ConcentrationNephronsPhosphatesPotassiumProteinsSodiumWaterWater-Electrolyte BalancePhosphatesPotassiumProteinsSodiumWaterkidneynephronrenal physiology

Identifiers

PMID24789550
PMCPMC4078957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.