ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
A polysaccharide from pomegranate peels induces the apoptosis of human osteosarcoma cells via the mitochondrial apoptotic pathway.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 31 citations in OpenAlex.
- Nanoemulsion encapsulation enhanced the anti-tumor potency of pomegranate polysaccharides by suppressing oxidative stress, inflammation, and tumor metastasis induced by 1,2-dimethylhydrazine in rats.Medical oncology (Northwood, London, England) · 2025Article
- Exploring Punicalagin Potential Against Cancers: A Comprehensive Review.Food science & nutrition · 2025Review
- Antitumoral properties of the pomegranate peel and blueberry extracts against tongue carcinoma (The Saudi dental journal · 2023Article
- The Temperature Influence on Drying Kinetics and Physico-Chemical Properties of Pomegranate Peels and Seeds.Foods (Basel, Switzerland) · 2023Article
- Article
- Analysis of the Phytochemical Composition of Pomegranate Fruit Juices, Peels and Kernels: A Comparative Study on Four Cultivars Grown in Southern Italy.Plants (Basel, Switzerland) · 2021Article
- Modulation of Apoptosis by Plant Polysaccharides for Exerting Anti-Cancer Effects: A Review.Frontiers in pharmacology · 2020Review
- Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochromeOncology letters · 2018Article
- Induction of S phase arrest and apoptosis by ethyl acetate extract from Tetrastigma hemsleyanum in human hepatoma HepG2 cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- (-)-Epigallocatechingallate induces apoptosis in B lymphoma cells via caspase-dependent pathway and Bcl-2 family protein modulation.International journal of oncology · 2015Article
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Authors and funding
3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Pomegranate (Punica granatum L.) peels, as one of the most valuable by-products of the food industry, has attracted much attention due to its wide range of bioactivities. In this study, the potential anticancer effect of a polysaccharide from pomegranate peels (PPP) on human osteosarcoma cancer cells was investigated. PPP was found to induce the arrest of G2/M phase, induce apoptosis, and inhibit the growth of U-2 osteosarcoma (OS) cells in a dose-dependent manner. Moreover, Western blotting analysis showed that PPP triggered the mitochondrial apoptotic pathway, as indicated by an increase in Bax/Bcl-2 ratios, a loss of mitochondrial membrane potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP) in U-2 OS cells. Our results indicate that PPP inhibits the proliferation of human osteosarcoma cancer cells by inducing apoptosis through the intrinsic mitochondrial pathway.
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