Evidence map›Paper›PMID 24789421›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014

Chemotherapy-induced peripheral neuropathy and its association with quality of life: a systematic review.

Floortje Mols, Tonneke Beijers, Gerard Vreugdenhil, Lonneke van de Poll-Franse

4 registry-linked trialsAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 197 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03571334 phase2recruitingnot on this mapstarted 2020, after this paper: background citation

Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy

TypeinterventionalSponsorMedical College of WisconsinRan2020 to 2024Enrolled40ConditionsPeripheral Neuropathy Due to ChemotherapyArmsIncobotulinumtoxinA (Xeomin®, Merz) (INA), Normal saline
NCT04201561 phase3unknown statusnot on this mapstarted 2019, after this paper: background citation

Safety and Efficacy of High Dose Inorganic seLenium for Preventing Chemotherapy Induced pEripheral Neuropathy in platINUM Sensitive Recurrent Ovarian, Fallopian, Primary Peritoneal Cancer: Phase III Randomised Controlled Trial

TypeinterventionalSponsorSeoul National University HospitalRan2019 to 2024Enrolled68ConditionsChemotherapy-induced Peripheral Neuropathy, Recurrent Ovarian Carcinoma, Ovarian Cancer, Fallopian Tube CancerArmssodium selenite pentahydrate, Normal saline, Chemotherapy
NCT04732455 nacompletednot on this mapstarted 2021, after this paper: background citation

Intravenous Lidocaine Infusion Versus Oral Duloxetine For The Prevention And Treatment Of Chemotherapy Induced Peripheral Neuropathy Among Breast Cancer Patients

TypeinterventionalSponsorGamal Mohamed Taha AbouelmagdRan2021 to 2022Enrolled60ConditionsPeripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy, Breast CancerArmsLidocaine in Saline, Duloxetine 30 MG, Normal saline
NCT06696976 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Telerehabilitation Versus Clinical Rehabilitation on Neuropathic Pain, Physical Function and Quality of Life in Chemotherapy Induced Peripheral Neuropathy

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled66ConditionsChemotherapy Induced Peripheral NeuropathyArmsTelerehabilitation, Clinical rehabilitation
3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 12 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Cognitive impairments associated with chemotherapy in women with breast cancer: a meta-analysis and meta-regression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023
    Pooled it
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  9. Goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
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  13. Trial
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  16. Supportive care: Comparing exercise interventions for upper extremity polyneuropathy induced by chemo- or immunotherapy - VISCIPH B.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Trial
  17. Effects of intermittent hand-foot hypothermia therapy on chemotherapy-induced peripheral neurotoxicity.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  18. Overall side effect assessment of oxaliplatin toxicity in rectal cancer patients in NRG oncology/NSABP R04.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Trial
  19. Trial
  20. Trial

137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Floortje MolsCoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, PO Box 90153, 5000 LE, Tilburg, The Netherlands, F.Mols@tilburguniversity.edu.
Tonneke Beijers
Gerard Vreugdenhil
Lonneke van de Poll-Franse

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this study was to systematically review all available literature concerning chemotherapy-induced peripheral neuropathy (CIPN) and quality of life (QOL) among cancer patients.

methodsA computerized search of the literature was performed in December 2013. Articles were included if they investigated CIPN and QOL among cancer patients. Twenty-five articles were selected and were subjected to a 13-item quality checklist independently by two investigators.

resultsThe methodological quality of the majority of the selected studies was adequate to high. The included studies differed tremendously with respect to study design (19 prospective studies, 5 cross-sectional, 1 both cross-sectional and prospective), patient population (lung, colorectal, ovarian, endometrial, cervical or breast cancer, lymphoma, acute lymphoblastic leukemia, or a mixed population), number of included patients (ranging from 14 to 1643), and ways to assess CIPN (objectively, subjectively, or both). Of the 25 included studies, 11 assessed the association of CIPN on patients' QOL. While three of these studies did not find an association between CIPN and QOL, the others concluded that more CIPN was associated with a lower QOL. IMPLICATIONS FOR CANCER SURVIVORS: Although the included studies in this systematic review were very diverse, which impedes drawing firm conclusions on this topic, CIPN is likely to have a negative association with QOL. The variety of the studied patient populations and chemotherapeutic agents in the existing studies calls for further studies on this topic. These studies are preferably prospective in nature, include a large number of patients, and assess QOL and CIPN with validated questionnaires.

Indexed as

Antineoplastic AgentsHumansInduction ChemotherapyNeoplasmsPeripheral Nervous System DiseasesQuality of LifeAntineoplastic Agents

Identifiers

PMID24789421

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.