ArticleLab on a chip2014
Microfluidics for single-cell genetic analysis.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of ESR1 mutation detection by cell-free DNA in breast cancer: a systematic review and meta-analysis of diagnostic test accuracy.BMC cancer · 2024Pooled it
- Droplet Microfluidics for Advanced Single-Cell Analysis.Smart medicine · 2025Review
- Controlling fluid flow rate to separate leukocytes and cancer cells based on stiffness differences.Mikrochimica acta · 2025Article
- Development of Nano-Micro Fused LSPR Chip for In Situ Single-Cell Secretion Analysis.Micromachines · 2023Article
- Integration of silicon chip microstructures for in-line microbial cell lysis in soft microfluidics.Lab on a chip · 2023Article
- Asymmetrical Obstacles Enable Unilateral Inertial Focusing and Separation in Sinusoidal Microchannel.Cyborg and bionic systems (Washington, D.C.) · 2023Article
- A Critical Review on the Sensing, Control, and Manipulation of Single Molecules on Optofluidic Devices.Micromachines · 2022Review
- Review of Microfluidic Methods for Cellular Lysis.Micromachines · 2021Review
- Review
- Enhanced single-cell encapsulation in microfluidic devices: From droplet generation to single-cell analysis.Biomicrofluidics · 2020Review
- Real-Time Monitoring and Detection of Single-Cell Level Cytokine Secretion Using LSPR Technology.Micromachines · 2020Article
- Single-cell patterning technology for biological applications.Biomicrofluidics · 2019Review
- Microfluidic Technologies for cfDNA Isolation and Analysis.Micromachines · 2019Review
- Machine-assisted cultivation and analysis of biofilms.Scientific reports · 2019Article
- An acoustofluidic trap and transfer approach for organizing a high density single cell array.Lab on a chip · 2018Article
- Article
- Translating microfluidics: Cell separation technologies and their barriers to commercialization.Cytometry. Part B, Clinical cytometry · 2017Review
- Single-cell isolation by a modular single-cell pipette for RNA-sequencing.Lab on a chip · 2016Article
- Direct Correlation between Motile Behavior and Protein Abundance in Single Cells.PLoS computational biology · 2016Article
- Development of Droplet Microfluidics Enabling High-Throughput Single-Cell Analysis.Molecules (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The ability to correlate single-cell genetic information to cellular phenotypes will provide the kind of detailed insight into human physiology and disease pathways that is not possible to infer from bulk cell analysis. Microfluidic technologies are attractive for single-cell manipulation due to precise handling and low risk of contamination. Additionally, microfluidic single-cell techniques can allow for high-throughput and detailed genetic analyses that increase accuracy and decrease reagent cost compared to bulk techniques. Incorporating these microfluidic platforms into research and clinical laboratory workflows can fill an unmet need in biology, delivering the highly accurate, highly informative data necessary to develop new therapies and monitor patient outcomes. In this perspective, we describe the current and potential future uses of microfluidics at all stages of single-cell genetic analysis, including cell enrichment and capture, single-cell compartmentalization and manipulation, and detection and analyses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.