ArticleCurrent protocols in toxicology2014
Developmental toxicity assays using the Drosophila model.
Article in Current protocols in toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
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- Assessing the role of the gut microbiome in methylmercury demethylation and elimination in humans and gnotobiotic mice.Archives of toxicology · 2023Article
- Assessment of Chemical Toxicity in Adult Drosophila Melanogaster.Journal of visualized experiments : JoVE · 2023Article
- Synthesis of chromium-D-phenylalanine complex and exploring its effects on reproduction and development inFrontiers in pharmacology · 2023Article
- Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in Transgenic Drosophila.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Motor dysfunction iniScience · 2022Article
- Looking at Developmental Neurotoxicity Testing from the Perspective of an Invertebrate Embryo.International journal of molecular sciences · 2022Review
- Inhibition ofBioMed research international · 2022Article
- Neuroligin-1 Is a Mediator of Methylmercury Neuromuscular Toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
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- In vivo evaluation of the toxicity, genotoxicity, histopathological, and anti-inflammatory effects of the purified bioglycerol byproduct in biodiesel industry.Journal, genetic engineering & biotechnology · 2020Article
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- Evaluation of the Antibacterial Activity and Efflux Pump Reversal of Thymol and Carvacrol againstMolecules (Basel, Switzerland) · 2020Article
- Volatile Organic Compounds Produced by Human Pathogenic Fungi Are Toxic toFrontiers in fungal biology · 2020Article
- Silver nanoparticle-induced developmental inhibition of Drosophila melanogaster accompanies disruption of genetic material of larval neural stem cells and non-neuronal cells.Environmental monitoring and assessment · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The fruit fly (Drosophila melanogaster) has long been a premier model for developmental biologists and geneticists. In toxicology studies, Drosophila has only recently gained broader recognition as a tool to elaborate molecular genetic mechanisms of toxic substances. In this article, two practical applications of Drosophila for developmental toxicity assays are described. The first assay takes advantage of newly developed methods to render the fly embryo accessible to small molecules, toxicants, and drugs. The second assay engages straightforward exposures to developing larvae and easy-to-score outcomes of adult development. With the extensive collections of flies that are publicly available and the ease of creating transgenic flies, these two assays have a unique power for identifying and characterizing molecular mechanisms and cellular pathways specific to the mode of action of a number of toxicants and drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.