Evidence map›Paper›PMID 24789197›Full record

ArticleJournal of clinical microbiology2014

Viral load detection using dried blood spots in a cohort of HIV-1-infected children in Uganda: correlations with clinical and immunological criteria for treatment failure.

Paola Costenaro, Rebecca Lundin, Maria Raffaella Petrara, Martina Penazzato, William Massavon, Susan Kizito, Sandra Monica Nabachwa, Maria Nannyonga Musoke, Charles Namisi, Erika Morelli and 5 more

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Evaluation of dried blood spot protocols with the Bio-Rad GS HIV Combo Ag/Ab EIA and Geenius™ HIV 1/2 Supplemental Assay.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2017
    Article
  6. Article
  7. Article
  8. Measures of viral load using Abbott RealTime HIV-1 Assay on venous and fingerstick dried blood spots from provider-collected specimens in Malawian District Hospitals.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paola CostenaroDepartment of Pediatrics, University of Padua, Padua, Italy paolacoste@gmail.com.
Rebecca LundinDepartment of Pediatrics, University of Padua, Padua, Italy.
Maria Raffaella PetraraDepartment of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, AIDS Reference Center, University of Padua, Padua, Italy.
Martina PenazzatoDepartment of Pediatrics, University of Padua, Padua, Italy.
William MassavonDepartment of Pediatrics, University of Padua, Padua, Italy.
Susan KizitoNsambya Home Care Department of St. Raphael of St. Francis Nsambya Hospital, Kampala, Uganda.
Sandra Monica NabachwaNsambya Home Care Department of St. Raphael of St. Francis Nsambya Hospital, Kampala, Uganda.
Maria Nannyonga MusokeNsambya Home Care Department of St. Raphael of St. Francis Nsambya Hospital, Kampala, Uganda.
Charles NamisiNsambya Home Care Department of St. Raphael of St. Francis Nsambya Hospital, Kampala, Uganda.
Erika MorelliDepartment of Pediatrics, University of Padua, Padua, Italy.
Davide BilardiDepartment of Pediatrics, University of Padua, Padua, Italy.
Antonio MazzaAssociazione Casa Accoglienza alla Vita Padre Angelo, Trento, Italy.
Marisa ZanchettaDepartment of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, AIDS Reference Center, University of Padua, Padua, Italy.
Carlo GiaquintoDepartment of Pediatrics, University of Padua, Padua, Italy.
Anita De RossiDepartment of Surgery, Oncology and Gastroenterology, Section of Oncology and Immunology, AIDS Reference Center, University of Padua, Padua, Italy Istituto Oncologico Veneto (IOV)-IRCCS, Padua, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Correlations between clinical/immunological treatment failure and viral load (VL) detected by dried blood spot (DBS) sampling were explored in HIV-1-infected children in Uganda. Of 104 children on combined antiretroviral treatment (cART), 12.5% experienced clinical and/or immunological failure, while 28.8%, 44.2%, and 26.9% had VLs of <1,000, 1,000 to 5,000, and >5,000 copies/ml, respectively. Clinical/immunological failure poorly predicted virological failure.

Indexed as

Anti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBloodChildChild, PreschoolCohort StudiesDesiccationFemaleHIV-1HIV InfectionsHumansMaleSensitivity and SpecificitySpecimen HandlingTreatment FailureUgandaAnti-Retroviral Agents

Identifiers

PMID24789197
PMCPMC4097737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.