Evidence map›Paper›PMID 24789186›Full record

ArticleJournal of clinical microbiology2014

Clinical, morphological, and molecular characterization of Penicillium canis sp. nov., isolated from a dog with osteomyelitis.

Daniel K Langlois, Deanna A Sutton, Cheryl L Swenson, Chris J Bailey, Nathan P Wiederhold, Nathan C Nelson, Elizabeth H Thompson, Brian L Wickes, Stephanie French, Jianmin Fu and 2 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. DisseminatedMedical mycology case reports · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Granulomatous polyarthritis caused byJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020
    Article
  8. Taxonomy and evolution ofComputational and structural biotechnology journal · 2018
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Daniel K LangloisDepartment of Small Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing, Michigan, USA langlo21@cvm.msu.edu stephen.peterson@ars.usda.gov.
Deanna A SuttonFungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas, USA.
Cheryl L SwensonDepartment of Pathobiology and Diagnostic Investigation, Diagnostic Center for Population and Animal Health, Michigan State University College of Veterinary Medicine, East Lansing, Michigan, USA.
Chris J BaileyDepartment of Small Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing, Michigan, USA.
Nathan P WiederholdFungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas, USA.
Nathan C NelsonDepartment of Small Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing, Michigan, USA.
Elizabeth H ThompsonFungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas, USA.
Brian L WickesDepartment of Microbiology and Immunology, The University of Texas Health Science Center, San Antonio, Texas, USA.
Stephanie FrenchDepartment of Pathobiology and Diagnostic Investigation, Diagnostic Center for Population and Animal Health, Michigan State University College of Veterinary Medicine, East Lansing, Michigan, USA.
Jianmin FuFungus Testing Laboratory, Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas, USA.
Paulo Vilar-SaavedraDepartment of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, USA.
Stephen W PetersonBacterial Foodborne Pathogens and Mycology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, USDA, Peoria, Illinois, USA langlo21@cvm.msu.edu stephen.peterson@ars.usda.gov.
Michigan State University · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas Health Science Center · USAgricultural Research Service · USVirginia–Maryland College of Veterinary Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections caused by Penicillium species are rare in dogs, and the prognosis in these cases is poor. An unknown species of Penicillium was isolated from a bone lesion in a young dog with osteomyelitis of the right ilium. Extensive diagnostic evaluation did not reveal evidence of dissemination. Resolution of lameness and clinical stability of disease were achieved with intravenous phospholipid-complexed amphotericin B initially, followed by long-term combination therapy with terbinafine and ketoconazole. A detailed morphological and molecular characterization of the mold was undertaken. Sequence analysis of the internal transcribed spacer revealed the isolate to be closely related to Penicillium menonorum and Penicillium pimiteouiense. Additional sequence analysis of β-tubulin, calmodulin, minichromosome maintenance factor, DNA-dependent RNA polymerase, and pre-rRNA processing protein revealed the isolate to be a novel species; the name Penicillium canis sp. nov. is proposed. Morphologically, smooth, ovoid conidia, a greenish gray colony color, slow growth on all media, and a failure to form ascomata distinguish this species from closely related Penicillium species.

Indexed as

Amphotericin BAnimalsAntifungal AgentsCluster AnalysisDNA, FungalDNA, Ribosomal SpacerDog DiseasesDogsFemaleFungal ProteinsHistocytochemistryKetoconazoleMolecular Sequence DataNaphthalenesOsteomyelitisPenicilliumAmphotericin BAntifungal AgentsDNA, FungalDNA, Ribosomal SpacerFungal ProteinsKetoconazoleliposomal amphotericin BNaphthalenesTerbinafine

Identifiers

PMID24789186
PMCPMC4097727
OpenAlexW2121335157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.