ReviewHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2014
Role of the sympathetic nervous system in hypertension and hypertension-related cardiovascular disease.
Review in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Differential cardiovascular and autonomic responses to structurally distinct intermittent hypoxia paradigms in rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Lack of regional and whole body sympathetic normalization during antihypertensive drug treatment: a potential link for the residual risk.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Within-visit and short- and long-term between-visit blood pressure variability as predictors of cardiovascular events and mortality in elderly Chinese.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Gut microbiota connects the brain and the heart: potential mechanisms and clinical implications.Psychopharmacology · 2024Review
- Renal Denervation in End-Stage Renal Disease: Current Evidence and Perspectives.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Review
- [Characterization of metabotropic glutamate receptor 7 and 8 in rat superior cervical ganglion and their changes following chronic intermittent hypoxia].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- MicroRNAs Regulating Renin-Angiotensin-Aldosterone System, Sympathetic Nervous System and Left Ventricular Hypertrophy in Systemic Arterial Hypertension.Biomolecules · 2021Review
- Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia.Scientific reports · 2021Article
- Dysregulation of the Excitatory Renal Reflex in the Sympathetic Activation of Spontaneously Hypertensive Rat.Frontiers in physiology · 2021Article
- Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes.Diabetologia · 2020Article
- Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats.Neuroscience bulletin · 2020Article
- Multiple Hits in Acute Pancreatitis: Components of Metabolic Syndrome Synergize Each Other's Deteriorating Effects.Frontiers in physiology · 2019Article
- Seasonal differences in brown adipose tissue density and pulse rate variability in a thermoneutral environment.Journal of physiological anthropology · 2018Article
- Superoxide Anions and NO in the Paraventricular Nucleus Modulate the Cardiac Sympathetic Afferent Reflex in Obese Rats.International journal of molecular sciences · 2017Article
- Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk?Nutrients · 2017Article
- The proinflammatory cytokine tumor necrosis factor-α excites subfornical organ neurons.Journal of neurophysiology · 2017Article
- Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease.Scientific reports · 2016Article
- Sympathetic-mediated activation versus suppression of the immune system: consequences for hypertension.The Journal of physiology · 2016Review
- Autonomic dysfunction, immune regulation, and multiple sclerosis.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of cardiovascular disease have been shown to be characterized by a marked increase in sympathetic drive to the heart and the peripheral circulation. This is the case for essential hypertension, congestive heart failure, cardiac arrhythmias, obesity, metabolic syndrome, obstructive sleep apnea, and chronic renal disease. This review focuses on the most recent findings documenting the role of sympathetic neural factors in the development and progression of the hypertensive state as well as in the pathogenesis of hypertension-related target organ damage. It also reviews the role of sympathetic neural factors in the development of cardiovascular diseases not necessarily strictly related to the hypertensive state, such as congestive heart failure, cardiac arrhythmias, obesity, metabolic syndrome and renal failure. The paper will finally review the pharmacological and non-pharmacological interventions acting on the sympathetic drive. Emphasis will be given to the new approaches, such as renal nerves ablation and carotid baroreceptor stimulation, which have been shown to exert sympathoinhibitory effects.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.