ArticleAngewandte Chemie (International ed. in English)2014
Ester carbonyl vibration as a sensitive probe of protein local electric field.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Integrative taxonomic and phytopharmacological analysis of ethnobotanical Acanthaceae species from Manipur, India.Scientific reports · 2026Article
- Machine learning potentials accurately reproduce vibrational dynamics in complex environments.The Journal of chemical physics · 2025Article
- Photocontrolled Release of Urea Enables the Detection of Urea-Urease Intermediates by Cryo-FTIR.Angewandte Chemie (International ed. in English) · 2025Article
- Lipid mediated formation of antiparallel aggregates in cerebral amyloid angiopathy.Acta neuropathologica · 2025Article
- Expanding the toolbox for supramolecular chemistry: probing host-guest interactions and binding withChemical science · 2025Article
- Local Interactions in Aqueous Ethanol Solution Revealed by the C=O Stretching Probe.Molecules (Basel, Switzerland) · 2025Article
- Hydrogen Bond Blueshifts in Nitrile Vibrational Spectra Are Dictated by Hydrogen Bond Geometry and Dynamics.JACS Au · 2024Article
- Direct observation of peptide hydrogel self-assembly.Chemical science · 2022Article
- Probing the Hydrogen-Bonding Environment of Individual Bases in DNA Duplexes with Isotope-Edited Infrared Spectroscopy.The journal of physical chemistry. B · 2021Article
- Nano-FTIR spectroscopic identification of prebiotic carbonyl compounds in Dominion Range 08006 carbonaceous chondrite.Scientific reports · 2021Article
- Vibrational Spectroscopic Map, Vibrational Spectroscopy, and Intermolecular Interaction.Chemical reviews · 2020Review
- Unperturbed Detection of the Dynamic Structure in the Hydrophobic Core of Trp-Cage via Two-Dimensional Infrared Spectroscopy.The journal of physical chemistry letters · 2020Article
- 4-Oxoproline as a Site-Specific Infrared Probe: Application To Assess Proline Isomerization and Dimer Formation.The journal of physical chemistry. B · 2019Article
- Glutamine Side ChainJournal of the American Chemical Society · 2019Article
- Site-Specific 1D and 2D IR Spectroscopy to Characterize the Conformations and Dynamics of Protein Molecular Recognition.The journal of physical chemistry. B · 2019Article
- Vibrational Approach to the Dynamics and Structure of Protein Amyloids.Molecules (Basel, Switzerland) · 2019Review
- Ultrafast Hydrogen-Bonding Dynamics in Amyloid Fibrils.The journal of physical chemistry. B · 2018Article
- Possible Existence of α-Sheets in the Amyloid Fibrils Formed by a TTRJournal of the American Chemical Society · 2018Article
- Fermi resonance as a means to determine the hydrogen-bonding status of two infrared probes.Physical chemistry chemical physics : PCCP · 2017Article
- Simple method to introduce an ester infrared probe into proteins.Protein science : a publication of the Protein Society · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The ability to quantify the local electrostatic environment of proteins and protein/peptide assemblies is key to gaining a microscopic understanding of many biological interactions and processes. Herein, we show that the ester carbonyl stretching vibration of two non-natural amino acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methyl ester, is a convenient and sensitive probe in this regard, since its frequency correlates linearly with the local electrostatic field for both hydrogen-bonding and non-hydrogen-bonding environments. We expect that the resultant frequency-electric-field map will find use in various applications. Furthermore, we show that, when situated in a non-hydrogen-bonding environment, this probe can also be used to measure the local dielectric constant (ε). For example, its application to amyloid fibrils formed by Aβ(16-22) revealed that the interior of such β-sheet assemblies has an ε value of approximately 5.6.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.