SynthesisCurrent hypertension reports2014
Glutathione-S-transferase M1 and T1 null genotypes are associated with hypertension risk: a systematic review and meta-analysis of 12 studies.
Synthesis in Current hypertension reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Polymorphisms in GSTT1 and GSTM1 genes as possible risk factors for susceptibility to breast cancer development and their influence in chemotherapy response: a systematic review.Molecular biology reports · 2020Pooled it
- Glutathione S-Transferase M1 and T1 polymorphisms and hypertension risk: an updated meta-analysis.Journal of human hypertension · 2019Pooled it
- Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null polymorphisms and the risk of hypertension: a meta-analysis.PloS one · 2015Pooled it
- Impaired Oxidative Status Is Strongly Associated with Cardiovascular Risk Factors.Oxidative medicine and cellular longevity · 2017Trial
- The relationship between liver enzymes, prehypertension and hypertension in the Azar cohort population.BMC cardiovascular disorders · 2024Article
- Article
- The good Samaritan glutathione-S-transferase P1: An evolving relationship in nitric oxide metabolism mediated by the direct interactions between multiple effector molecules.Redox biology · 2023Review
- Glutathione-Biomolecules · 2022Article
- Review
- Effects of GSTT1 and GSTM1 polymorphisms in glutathione levels and breast cancer development in Brazilian patients.Molecular biology reports · 2021Article
- Oxidative Stress: A Unifying Paradigm in Hypertension.The Canadian journal of cardiology · 2020Review
- Association between serum liver enzymes and hypertension: a cross-sectional study in Bangladeshi adults.BMC cardiovascular disorders · 2020Article
- Reactive oxygen species: key regulators in vascular health and diseases.British journal of pharmacology · 2018Review
- Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases.Oncogenesis · 2018Review
- Genomic structural variations for cardiovascular and metabolic comorbidity.Scientific reports · 2017Article
- Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans.Oxidative medicine and cellular longevity · 2017Review
- Hypertension as an autoimmune and inflammatory disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Review
- Associations analysis of GSTM1, T1 and P1 Ile105Val polymorphisms with carpal tunnel syndrome.Clinical rheumatology · 2016Article
- No association betweenMolecular biology research communications · 2016Article
- Potential biomarkers and targets in reversibility of pulmonary arterial hypertension secondary to congenital heart disease: an explorative study.Pulmonary circulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is known to be implicated in the pathogenesis of essential hypertension. Glutathione-S-transferase (GST) enzymes are key components of cellular defense against oxidative stress. The present study aimed to clarify the association between polymorphisms in GST and risk of essential hypertension using a meta-analysis of published studies. PubMed-Medline, Ovid-EMBASE, HuGE Navigator and SCOPUS databases were searched to identify case-control studies that examined the association of GST polymorphisms and hypertension. Data were extracted using standardized methods. Combined odds ratios (OR) with 95% confidence intervals (CI) for the association of polymorphisms with hypertension were calculated using a fixed effect approach and under dominant, recessive, additive and overdominant models of inheritance. A total of 12 studies comprising 2,040 cases and 2,462 controls fulfilled the inclusion criteria. GSTM1 (presence/null), GSTT1 (presence/null) and GSTP1 (Ile105Val; rs1695) polymorphisms were evaluated. Meta-analysis revealed significant associations between the null genotypes of GSTM1 (OR: 1.22; 95% CI: 1.08-1.39; p=0.002) and GSTT1 (OR: 1.30; 95% CI: 1.13-1.50; p=0.0003) and risk of hypertension. The observed associations were robust in sensitivity analyses. However, no significant association was found for the rs1695 polymorphism under all assessed modes of inheritance. Findings of the present meta-analysis demonstrated that GSTM1 and GSTT1 null genotypes may serve as predisposing factors for essential hypertension. Further studies are warranted to validate this association, and also to explore if these null genotypes are in linkage with other hypertension susceptibility polymorphisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.