ArticlePloS one2014
Stress exacerbates infectivity and pathogenicity of Blastocystis hominis: in vitro and in vivo evidences.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Effects of the Healing Beats Program among University Students after Exposure to a Source of Psychological Stress: A Randomized Control Trial.International journal of environmental research and public health · 2021Trial
- Assessment of the Therapeutic Role of Allium tuncelianum Extract in Rats Infected with Blastocystis Subtype 3.Acta parasitologica · 2025Article
- Assessing Zoonotic Risks ofPathogens (Basel, Switzerland) · 2025Article
- Atypical Presentation ofInternational medical case reports journal · 2025Article
- Prevalence and molecular identification of protozoan intestinal parasitic infections in cancer patients and a control group.BMC infectious diseases · 2024Article
- Higher amoebic and metronidazole resistant forms of Blastocystis sp. seen in schizophrenic patients.Parasites & vectors · 2022Article
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- Prevalence of Intestinal Parasitic Infection in Cancer, Organ Transplant and Primary Immunodeficiency Patients in Tehran, IranAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Effect of Blastocystis sp. in dengue patients-Increase in the treatment cost and exacerbation of symptoms.PloS one · 2019Article
- Alterations in oxidative stress parameters and its associated correlation with clinical disease on experimentalJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Exacerbation of colon carcinogenesis by Blastocystis sp.PloS one · 2017Article
- Corticosterone: a costly mediator of signal honesty in sand lizards.Ecology and evolution · 2016Article
- A tale of two communities: intestinal polyparasitism among Orang Asli and Malay communities in rural Terengganu, Malaysia.Parasites & vectors · 2016Article
- Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update.PLoS neglected tropical diseases · 2015Review
- Prevalence of intestinal opportunistic parasites infections in the University hospital of Bobo-Dioulasso, Burkina Faso.Infectious diseases of poverty · 2015Article
- Article
- OCCURRENCE OF Blastocystis spp. IN UBERABA, MINAS GERAIS, BRAZIL.Revista do Instituto de Medicina Tropical de Sao PauloArticle
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundStress alters the oxidant-antioxidant state and immune cell responses which disrupts its function to combat infection. Blastocystis hominis, a common intestinal protozoan has been reported to be opportunistic in immunocompromised patients namely cancer. B. hominis infectivity in other altered immune system conditions especially stress is unknown. We aimed to demonstrate the stress effects towards the susceptibility and pathogenicity of B. hominis infection. METHODS/
findingsThree-week-old Wistar rats were divided into four groups: (a)control; (b)stress-induced; (c)B. hominis infected; (d)stress-induced with B. hominis infection; (n = 20 respectively). Stress was induced for an hour daily (30 days) using a Belly Dancer Shaker. Weight gain was monitored, stool samples were collected for B. hominis screening and blood for the determination of differential count, levels of immunoglobulin, oxidative damage, and peripheral blood mononuclear cell (PBMC) proliferation upon induction with solubilized antigen of B. hominis (Blasto-Ag). Group (b) exhibited the highest level of weight gain. Group (d) had higher levels of parasite cyst count in stools, serum IgE, oxidized protein and lipid compared to the group (c). Levels of monocyte and antioxidant in group (d) were decreased and their PBMCs showed highest inhibition of proliferation level when exposed to Blasto-Ag. Monocyte level in Group (b) showed insignificant difference compared to group (a) but was significantly lower compared to group (c). Antioxidant levels in group (c) were generally lower compared to group (a) and (b). Inhibition level exhibited by Blasto-Ag treated PBMCs of group (c) was higher compared to group (a) and (b).
conclusionThe pathogenicity and augmentation of B. hominis infection is enhanced when stress is present. Lifestyles today are becoming increasingly stressed and the present findings suggest that the parasite which has been reported to be one of the most common organisms seen in stool surveys, namely in developing countries, may tend to be more pathogenic in stressful situations.
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