ArticlePLoS pathogens2014
A nasal epithelial receptor for Staphylococcus aureus WTA governs adhesion to epithelial cells and modulates nasal colonization.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 118 citations in OpenAlex.
- Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026Review
- Phage Intolerance Impacts Antibiotic Susceptibility and Virulence in Staphylococcus aureus.Current microbiology · 2026Article
- Synergistic Induction of Neutrophilic Inflammatory Programs byImmune network · 2026Article
- Methicillin-resistantAntimicrobial agents and chemotherapy · 2026Article
- Examining the role of IgA in a persistent model of Staphylococcus aureus colonization.PLoS pathogens · 2026Article
- Dual glycosylation of wall teichoic acid modulates the O-antigen pattern and virulence in serovar 4bmLife · 2025Article
- Murine model of antibiotic-associated Staphylococcus aureus gastrointestinal infections (SAGII) and colonization.Gut pathogens · 2025Article
- ThemBio · 2025Article
- Bordetellae colonization oligosaccharide (b-Cool), a glycan crucial for nasal colonization.Science advances · 2025Article
- TEAL-Seq: targeted expression analysis sequencing.mSphere · 2025Article
- The Ligand Binding Domain of the Cell Wall Protein SraP Modulates Macrophage Apoptosis and Inflammatory Responses inMolecules (Basel, Switzerland) · 2025Article
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- Comparison of the bacterial microbiome in the pharynx and nasal cavity of persistent, intermittent carriers and non-carriers ofJournal of medical microbiology · 2024Article
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- Phenotypic Variation inAntibiotics (Basel, Switzerland) · 2024Review
- Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs.Archives of microbiology · 2024Review
- Staphylococcus aureus colonisation and strategies for decolonisation.The Lancet. Microbe · 2024Review
- Cryo-EM analysis ofScience advances · 2024Article
- Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus.Nature microbiology · 2024Article
- Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation.Biofilm · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedFaulstich, Manuela [corrected to Faulstich, Michaela]
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal colonization is a major risk factor for S. aureus infections. The mechanisms responsible for colonization are still not well understood and involve several factors on the host and the bacterial side. One key factor is the cell wall teichoic acid (WTA) of S. aureus, which governs direct interactions with nasal epithelial surfaces. We report here the first receptor for the cell wall glycopolymer WTA on nasal epithelial cells. In several assay systems this type F-scavenger receptor, termed SREC-I, bound WTA in a charge dependent manner and mediated adhesion to nasal epithelial cells in vitro. The impact of WTA and SREC-I interaction on epithelial adhesion was especially pronounced under shear stress, which resembles the conditions found in the nasal cavity. Most importantly, we demonstrate here a key role of the WTA-receptor interaction in a cotton rat model of nasal colonization. When we inhibited WTA mediated adhesion with a SREC-I antibody, nasal colonization in the animal model was strongly reduced at the early onset of colonization. More importantly, colonization stayed low over an extended period of 6 days. Therefore we propose targeting of this glycopolymer-receptor interaction as a novel strategy to prevent or control S. aureus nasal colonization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.