ArticleVirus genes2014
Characterization of complete genome sequence of genotype VI and VII velogenic Newcastle disease virus from Japan.
Article in Virus genes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 42 citations in OpenAlex.
- Whole-genome characterization of Newcastle disease virus isolates of sub-genotype VII.1.1 from chickens in Ethiopia.Virus genes · 2025Article
- Genetic Diversity of Newcastle Disease Virus and Its Implications for Vaccine Development.Veterinary sciences · 2025Review
- Newcastle disease virus in Egyptian domestic poultry, 2019-2021: Molecular characterization, phylogenetic analysis, and coinfection with avian influenza A virus.Open veterinary journal · 2025Article
- Two Outbreaks of Pigeon Paramyxovirus 1 With High Mortality in Captive Pigeons (Transboundary and emerging diseases · 2025Article
- Phylogenetic analysis, genetic diversity, and epidemiology of pigeon paramyxovirus type 1 in China.Archives of virology · 2024Article
- Molecular characteristics and phylogenetic analysis of pigeon paramyxovirus type 1 isolates from pigeon meat farms in Shanghai (2009-2012).Scientific reports · 2024Article
- Detection and molecular characterization of virulent Newcastle disease virus (subgenotype VII.2) in broiler chickens in Northern Vietnam.Veterinary world · 2023Article
- Introduction of a Newcastle disease virus challenge strain (sub-genotype VII.1.1) isolated in Iran.Veterinary research forum : an international quarterly journal · 2023Article
- Active Surveillance and Genetic Characterization of Prevalent Velogenic Newcastle Disease and Highly Pathogenic Avian Influenza H5N8 Viruses Among Migratory Wild Birds in Southern Egypt During 2015-2018.Food and environmental virology · 2022Article
- Continuous surveillance revealing a wide distribution of class I Newcastle disease viruses in China from 2011 to 2020.PloS one · 2022Article
- Innate immune responses of domestic pigeons to the infection of pigeon paramyxovirus type 1 virus.Poultry science · 2021Article
- Sequence analysis and pathogenicity of Avian Orthoavulavirus 1 strains isolated from poultry flocks during 2015-2019.BMC veterinary research · 2020Article
- Molecular characterization of full genome sequences of Newcastle disease viruses circulating among vaccinated chickens in Egypt during 2011-2013.The Journal of veterinary medical science · 2020Article
- Molecular and biological characterization of the immunological potency of Newcastle disease virus oil emulsion-inactivated vaccines prepared from field isolate obtained from vaccinated chickens outbreak.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Reverse Genetics Assembly of Newcastle Disease Virus Genome Template Using Asis-Sal-Pac BioBrick Strategy.Biological procedures online · 2020Article
- Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Article
- Molecular characterization of new emerging sub-genotype VIIh Newcastle disease viruses in China.Virus genes · 2019Article
- Viral infection detection using metagenomics technology in six poultry farms of eastern China.PloS one · 2019Article
- Pathobiology of Avian avulavirus 1: special focus on waterfowl.Veterinary research · 2018Review
- Genomic Characterizations of a Newcastle Disease Virus Isolated from Ducks in Live Bird Markets in China.PloS one · 2016Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete genome sequences of three strains of Newcastle disease virus (NDV) isolated from vaccinated commercial layer flocks in Japan in the span of three decades were characterized. All strains had genome lengths of 15,192 nucleotides consisting of six genes in the order of 3'-NP-P/V/W-M-F-HN-L-5'. The general genomic characteristics of the Japanese field strains were consistent with previously characterized class II NDV, except for those belonging to early genotypes (genotype I-IV), which lack the six nucleotide insertion at nucleotide positions 1,648-1,653 of the nucleoprotein (NP) gene. Phylogenetic analysis showed that the Japanese strains could be classified into genotypes VIc and VIIe using the complete genome sequence and the complete coding sequence of the fusion (F) gene according to the unified NDV classification system. Characterization of functional domains and neutralizing epitopes of the F and hemagglutinin-neuraminidase (HN) proteins of Japanese field strains revealed a total of 31 amino acid substitutions, as compared to vaccine strains Ishii and B1, which were widely used in Japan. Although virus neutralization (VN) test showed that poor flock immunity due to vaccination failure or partial and non-uniform immunization maybe the major factors involved in the mechanism of breakthrough infection of the Japanese field strains, approximately two to threefold decrease in the VN titers of the field NDV strains possessing a point mutation (E347K or E347G) at the linear epitope of the HN protein was observed, as compared to vaccine strain B1 and field strain 2440/69, which lack the point mutation. This study may be a useful reference in characterizing future ND outbreaks in vaccinated chickens and as a genetic map for future investigations regarding vaccine designs, reverse genetics systems, and development of molecular diagnostic tools to prevent future ND outbreaks in vaccinated poultry flocks.
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