ArticleLasers in surgery and medicine2014
Multimodal optical imaging can reveal changes in microcirculation and tissue oxygenation during skin wound healing.
Article in Lasers in surgery and medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07593352 (A Multicenter, Prospective, Observational Study Comparing the Prevalence of Renal Dysfunction in Adult Patient With Inflammatory Bowel Disease Between General Population), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Prospective, Observational Study Comparing the Prevalence of Renal Dysfunction in Adult Patient With Inflammatory Bowel Disease Between General Population: The NEPHRO-IBD Study.
Who cites it
11 citing papers in PubMed.
- Exploring fetal skeletal alterations induced by gold nanoparticles in mice confirmed by laser speckle imaging and LIBS approach.Biology direct · 2026Article
- Rapid Quantitative Imaging of Heterogeneous Tissue Hemoglobin Dynamics Using Spatial Frequency Domain Imaging.Journal of vascular research · 2026Article
- Long-term investigation of 3D tissue detailed structure and multiparametric vascular network properties using OCT/OCTA for guiding atopic dermatitis theranostics.Journal of translational medicine · 2025Article
- In vivo volumetric monitoring of revascularization of traumatized skin using extended depth-of-field photoacoustic microscopy.Frontiers of optoelectronics · 2020Article
- Imaging in Chronic Wound Diagnostics.Advances in wound care · 2020Review
- Recent trends in two-photon auto-fluorescence lifetime imaging (2P-FLIM) and its biomedical applications.Biomedical engineering letters · 2019Review
- Aging-associated changes in cerebral vasculature and blood flow as determined by quantitative optical coherence tomography angiography.Neurobiology of aging · 2018Article
- Optical coherence tomography based microangiography provides an ability to longitudinally image arteriogenesis in vivo.Journal of neuroscience methods · 2016Article
- Accessing to arteriovenous blood flow dynamics response using combined laser speckle contrast imaging and skin optical clearing.Biomedical optics express · 2015Article
- Assessment of microcirculation dynamics during cutaneous wound healing phases in vivo using optical microangiography.Journal of biomedical optics · 2014Article
- Does optical microangiography provide accurate imaging of capillary vessels?: validation using multiphoton microscopy.Journal of biomedical optics · 2014Article
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
objectiveFaster and better wound healing is a longstanding goal. Blood flow, angiogenesis, and tissue oxygenation are important parameters in evaluating the healing process. Optical microangiography (OMAG) allows 3D imaging of tissue vasculature and can provide quantitative blood flow information down to the capillary level of resolution. Dual wavelength laser speckle imaging (DW-LSI) can measure tissue oxygenation status. MATERIALS AND
methodsCutaneous wound healing of a mouse ear model using a multimodal imaging system that combines OMAG with DWLSI was studied.
resultsA complete microvasculature map of the ear in vivo was obtained. The imaging system revealed both hemodynamic and metabolic changes during acute stage wound healing. Blood flow velocity, blood flow direction, as well as changes in concentration of oxygenated hemoglobin (ΔHbO) and deoxygenated hemoglobin (ΔHb) were measured and quantified. In addition, capillary recruitment and angiogenesis were visualized during the chronic stage of repairing.
conclusionsThe combination of DW-LSI and OMAG imaging technique may be a powerful tool to visualize and understand microvascular, hemodynamic, and metabolic changes during cutaneous wound healing.
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