ArticleHerz2014
[Direct anticoagulants for atrial fibrillation. Update 2014].
Article in Herz, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- [Spontaneous intraocular hemorrhage under oral anticoagulation : Apixaban in comparison to phenprocoumon].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2018Article
- Review
- Compensatory caspase activation in MPP+-induced cell death in dopaminergic neurons.Cellular and molecular life sciences : CMLS · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For several decades vitamin K antagonists (VKA) were the standard for stroke prevention in atrial fibrillation. Because of inconvenience associated with their use (frequently VKA levels cannot be consistently maintained within the therapeutic range, e.g. due to food and drug interactions, which necessitates regular control of international normalized ratios) alternative compounds have recently been developed, the direct oral anticoagulants (DOACs) dabigatran (a direct antithrombin) as well as rivaroxaban, apixaban and edoxaban (direct factor Xa inhibitors). All these agents show a predictable pharmacokinetic profile making routine laboratory controls unnecessary. Moreover, DOACs do not only show a similar or even better efficacy, but also a more attractive safety profile in terms of similar or less major bleeding complications, where all DOACs significantly reduce the rate of intracranial bleeding when compared to VKAs. This review summarizes the pharmacological characteristics and clinical study results of DOACs that have been tested in phase 3 trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.