Evidence map›Paper›PMID 24788130›Full record

ArticleAJNR. American journal of neuroradiology2014

Complex hemodynamic insult in combination with wall degeneration at the apex of an arterial bifurcation contributes to generation of nascent aneurysms in a canine model.

J Wang, H-Q Tan, Y-Q Zhu, M-H Li, Z-Z Li, L Yan, Y-S Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J WangFrom the Department of Diagnostic and Interventional Radiology (J.W., H.-Q.T., Y.-Q.Z., M.-H.L., L.Y., Y.-S.C.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
H-Q TanFrom the Department of Diagnostic and Interventional Radiology (J.W., H.-Q.T., Y.-Q.Z., M.-H.L., L.Y., Y.-S.C.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Y-Q ZhuFrom the Department of Diagnostic and Interventional Radiology (J.W., H.-Q.T., Y.-Q.Z., M.-H.L., L.Y., Y.-S.C.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China zhuyueqi@hotmail.com liminghuaradio@hotmail.com.
M-H LiFrom the Department of Diagnostic and Interventional Radiology (J.W., H.-Q.T., Y.-Q.Z., M.-H.L., L.Y., Y.-S.C.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China zhuyueqi@hotmail.com liminghuaradio@hotmail.com.
Z-Z LiSchool of Mechanical Engineering (Z.-Z.L.), Shanghai Jiao Tong University, Shanghai, China.
L YanFrom the Department of Diagnostic and Interventional Radiology (J.W., H.-Q.T., Y.-Q.Z., M.-H.L., L.Y., Y.-S.C.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Y-S ChengFrom the Department of Diagnostic and Interventional Radiology (J.W., H.-Q.T., Y.-Q.Z., M.-H.L., L.Y., Y.-S.C.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThe detailed mechanisms of cerebral aneurysm generation remain unclear. Our aim was to investigate whether specific hemodynamic insult in combination with arterial wall degeneration leads to the development of aneurysms in a canine model. MATERIALS AND

methodsNew branch points in the common carotid artery were created in 18 dogs. Nine animals subsequently received elastase insult at the arterial bifurcation apex (elastase-treated bifurcation group); the control bifurcation group (n=9) received saline, and 3 dogs received an elastase insult to both straight common carotid arteries (elastase-treated straight group). Angiographic and hemodynamic analysis was performed immediately and 12 and 24 weeks' postsurgery; histologic response was evaluated at 12 and 24 weeks.

resultsAngiography revealed nascent aneurysms (mean, 3.2±0.4 mm) at the arterial bifurcation apices in 5/9 models of the elastase-treated bifurcation group (versus 0 in the control bifurcation group and elastase-treated straight group) without any observed aneurysm rupture. Histologic analysis revealed internal elastic lamina discontinuity, elastic fiber disruption, a thinner muscular layer, reduced smooth-muscle cell proliferation, increased inflammatory cell (macrophage) infiltration, and expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in the media of the elastase-treated bifurcation group compared with that in either the control bifurcation group or the elastase-treated straight group (P<.001). Hemodynamic analysis after surgery indicated that the apex experienced extremely low wall shear stress and flow velocity and the highest relative and total pressure in the elastase-treated bifurcation group, while the values returned to normal after arterial wall remodelling.

conclusionsIn our study, combined hemodynamic insult and arterial wall degeneration at arterial bifurcations are required for the generation of aneurysms in a canine model.

Indexed as

AnimalsCarotid Artery, CommonCerebral AngiographyDisease Models, AnimalDogsHemodynamicsIntracranial AneurysmStress, Mechanical

Identifiers

PMID24788130
PMCPMC7966285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.