ArticlePloS one2014
ComQXPA quorum sensing systems may not be unique to Bacillus subtilis: a census in prokaryotic genomes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Colocalisation of lanthipeptide production with genetic exchange and defence systems across prokaryote genomes.BMC genomics · 2025Article
- Activity dynamics and regulation mechanism of extracellular proteases inApplied and environmental microbiology · 2025Article
- Article
- Quorum sensing and antibiotic resistance in polymicrobial infections.Communicative & integrative biology · 2024Review
- Insights into the structure and function of the histidine kinase ComP from Bacillus amyloliquefaciens based on molecular modeling.Bioscience reports · 2022Article
- Salt TolerantPlants (Basel, Switzerland) · 2022Article
- A balanced gut microbiota is essential to maintain health in captive sika deer.Applied microbiology and biotechnology · 2022Article
- Evolution of two-component quorum sensing systems.Access microbiology · 2022Article
- Revealing plant growth-promoting mechanisms ofFrontiers in plant science · 2022Article
- Peptide signaling without feedback in signal production operates as a true quorum sensing communication system in Bacillus subtilis.Communications biology · 2021Article
- Article
- A Bacterial Tower of Babel: Quorum-Sensing Signaling Diversity and Its Evolution.Annual review of microbiology · 2020Review
- The ComX Quorum Sensing Peptide ofMicroorganisms · 2020Article
- Genetic Screening and Expression Analysis of PsychrophilicMicroorganisms · 2019Article
- A neural network model predicts community-level signaling states in a diverse microbial community.PLoS computational biology · 2019Article
- Social behaviours by Bacillus subtilis: quorum sensing, kin discrimination and beyond.Molecular microbiology · 2018Review
- ComX-Induced Exoproteases Degrade ComX inFrontiers in microbiology · 2018Article
- Genomic and molecular characterization of a novel quorum sensing molecule in Bacillus licheniformis.AMB Express · 2017Article
- The quorum-sensing regulator ComA from Bacillus subtilis activates transcription using topologically distinct DNA motifs.Nucleic acids research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The comQXPA locus of Bacillus subtilis encodes a quorum sensing (QS) system typical of Gram positive bacteria. It encodes four proteins, the ComQ isoprenyl transferase, the ComX pre-peptide signal, the ComP histidine kinase, and the ComA response regulator. These are encoded by four adjacent genes all situated on the same chromosome strand. Here we present results of a comprehensive census of comQXPA-like gene arrangements in 2620 complete and 6970 draft prokaryotic genomes (sequenced by the end of 2013). After manually checking the data for false-positive and false-negative hits, we found 39 novel com-like predictions. The census data show that in addition to B. subtilis and close relatives, 20 comQXPA-like loci are predicted to occur outside the B. subtilis clade. These include some species of Clostridiales order, but none outside the phylum Firmicutes. Characteristic gene-overlap patterns were observed in comQXPA loci, which were different for the B. subtilis-like and non-B. subtilis-like clades. Pronounced sequence variability associated with the ComX peptide in B. subtilis clade is evident also in the non-B. subtilis clade suggesting grossly similar evolutionary constraints in the underlying quorum sensing systems.
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