ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2014
Frequency of lymph node metastasis according to the size of tumors in resected pulmonary adenocarcinoma with a size of 30 mm or smaller.
Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 46 citations in OpenAlex.
- A Nomogram Based on Nutrition-Related Indicators and Computed Tomography Imaging Features for Predicting Preoperative Lymph Node Metastasis in Curatively Resected Esophagogastric Junction Adenocarcinoma.Annals of surgical oncology · 2023Trial
- Prognostic Significance of the Uncertain Resection Based on the Extent of Nodal Dissection in Non-small-Cell Lung Cancer.Annals of surgical oncology · 2026Article
- Predictive factors of response in lung metastases treated by sbrt from colon rectal cancer.Clinical & experimental metastasis · 2026Article
- Correlation of solid proportion and lymph node metastasis in lung cancers ≤30 mm in diameter.Quantitative imaging in medicine and surgery · 2025Article
- Prediction of Lung Cancer Metastasis Using Machine Learning Models Based on Clinical Laboratory Data.Cancer reports (Hoboken, N.J.) · 2025Article
- Overdiagnosis in Lung Cancer Screening: Still the Unavoidable Cost of Doing Business?Annals of thoracic surgery short reports · 2025Article
- Computed tomography characteristics of cN0 primary non-small cell lung cancer predict occult lymph node metastasis.European radiology · 2024Article
- Improving prediction accuracy of spread through air spaces in clinical-stage T1N0 lung adenocarcinoma using computed tomography imaging models.JTCVS open · 2024Article
- The impact of PET/CT and brain MRI for metastasis detection among patients with clinical T1-category lung cancer: Findings from a large-scale cohort study.European journal of nuclear medicine and molecular imaging · 2024Article
- Is tumor diameter a risk factor for occult N1 metastasis in patients with peripheral non-small cell lung cancer which is smaller than 3 cm?Updates in surgery · 2023Article
- Risk profiles and a concise prediction model for lymph node metastasis in patients with lung adenocarcinoma.Journal of cardiothoracic surgery · 2023Review
- Construction and Evaluation of a Preoperative Prediction Model for Lymph Node Metastasis of cIA Lung Adenocarcinoma Using Random Forest.Journal of oncology · 2022Article
- Development and validation of a preoperative noninvasive predictive model based on circular tumor DNA for lymph node metastasis in resectable non-small cell lung cancer.Translational lung cancer research · 2020Article
- Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer.The Journal of clinical investigation · 2020Article
- FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism.Theranostics · 2020Article
- Which patients benefit most from stereotactic body radiotherapy or surgery in medically operable non-small cell lung cancer? An in-depth look at patient characteristics on both sides of the debate.Thoracic cancer · 2019Review
- Approaches to stereotactic body radiation therapy for large (≥5 centimeter) non-small cell lung cancer.Translational lung cancer research · 2019Review
- Predictors of lymph node metastasis and possible selective lymph node dissection in clinical stage IA non-small cell lung cancer.Journal of thoracic disease · 2018Article
- Article
- Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer.The Journal of thoracic and cardiovascular surgery · 2015Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study analyzed the relation between the tumor size and the lymph node metastasis in adenocarcinoma of the lung with a size of 30 mm or smaller.
methodsFour hundred thirteen patients who had undergone curative resection for lung adenocarcinoma were enrolled. If the tumor presented ground-glass opacities on the preoperative high-resolution computed tomography, both the total size including ground-glass opacities and the solid size alone were measured. To calculate the rates of lymph node metastasis by the tumor size, the tumors were divided into six groups by their sizes: 5 mm or less, 6 to 10 mm, 11 to 15 mm, 16 to 20 mm, 21 to 25 mm, and 26 to 30 mm.
resultsThe average numbers of dissected lymph nodes and dissected lymph node stations were 17 and 5, respectively. Seventy-five patients (18%) were postoperatively discovered to have positive nodes. The rates of node metastasis in each total size group were 0/1 (0%), 0/29 (0%), 5/77 (7%), 17/121 (14%), 27/101 (27%), and 26/84 (31%), respectively. The rates of node metastasis in each solid size group were 0/37 (0%), 1/53 (2%), 9/88 (10%), 17/104 (16%), 23/78 (30%), and 25/53 (47%), respectively. The area under the curve of receiver operating characteristic curves for the total size was measured as 0.701, and that for the solid size was measured as 0.777. By multivariate analysis, solid size, maximum standardized uptake value, and lymphovascular invasion were independent significant predictive factors.
conclusionsSolid size, maximum standardized uptake value, and lymphovascular invasion were independent predictors for lymph node metastasis of lung adenocarcinoma. The size of the solid component explained the relation between the tumor size and the lymph node metastasis more accurately than that explained by the total tumor size on high-resolution computed tomography.
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