Evidence map›Paper›PMID 24787497›Full record

Trial reportThe American journal of clinical nutrition2014

Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults.

Nicola Napoli, Krupa Shah, Debra L Waters, David R Sinacore, Clifford Qualls, Dennis T Villareal

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00146107 (Weight Loss and Exercise in Frail Obese Elderly Subjects), which is not on this map. Cited by 78 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 10 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00146107 phase3completednot on this map

Weight Loss and Exercise in Frail Obese Elderly Subjects

TypeinterventionalSponsorWashington University School of MedicineRan2005 to 2010Enrolled107ConditionsObesityArmsDiet, Exercise, Weight Loss and Exercise
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 10 syntheses or guidelines pooled it, 165 citations in OpenAlex.

  1. Pooled it
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  4. Guideline
  5. Effect of exercise as adjuvant to energy-restricted diets on quality of life and depression outcomes: a meta-analysis of randomized controlled trials.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Pooled it
  6. Effect of exercise training on psychological outcomes in adults with overweight or obesity: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
  7. Pooled it
  8. Obesity and episodic memory function.The journal of physiological sciences : JPS · 2018
    Pooled it
  9. Does exercise training augment improvements in quality of life induced by energy restriction for obese populations? A systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
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  18. Effectiveness of A Pilates Training Program on Cognitive and Functional Abilities in Postmenopausal Women.International journal of environmental research and public health · 2020
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicola NapoliFrom the Division of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy (NN); the Division of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY (KS); the Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine, Dunedin, New Zealand (DLW); the Division of Geriatrics and Nutritional Science (DRS and DTV) and the Program in Physical Therapy (DRS), Washington University School of Medicine, St Louis, MO; the Department of Mathematics and Statistics (CQ) and the Division of Geriatrics (DTV), University of New Mexico School of Medicine, Albuquerque, NM; and the Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM (DTV).
Krupa ShahFrom the Division of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy (NN); the Division of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY (KS); the Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine, Dunedin, New Zealand (DLW); the Division of Geriatrics and Nutritional Science (DRS and DTV) and the Program in Physical Therapy (DRS), Washington University School of Medicine, St Louis, MO; the Department of Mathematics and Statistics (CQ) and the Division of Geriatrics (DTV), University of New Mexico School of Medicine, Albuquerque, NM; and the Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM (DTV).
Debra L WatersFrom the Division of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy (NN); the Division of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY (KS); the Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine, Dunedin, New Zealand (DLW); the Division of Geriatrics and Nutritional Science (DRS and DTV) and the Program in Physical Therapy (DRS), Washington University School of Medicine, St Louis, MO; the Department of Mathematics and Statistics (CQ) and the Division of Geriatrics (DTV), University of New Mexico School of Medicine, Albuquerque, NM; and the Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM (DTV).
David R SinacoreFrom the Division of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy (NN); the Division of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY (KS); the Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine, Dunedin, New Zealand (DLW); the Division of Geriatrics and Nutritional Science (DRS and DTV) and the Program in Physical Therapy (DRS), Washington University School of Medicine, St Louis, MO; the Department of Mathematics and Statistics (CQ) and the Division of Geriatrics (DTV), University of New Mexico School of Medicine, Albuquerque, NM; and the Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM (DTV).
Clifford QuallsFrom the Division of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy (NN); the Division of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY (KS); the Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine, Dunedin, New Zealand (DLW); the Division of Geriatrics and Nutritional Science (DRS and DTV) and the Program in Physical Therapy (DRS), Washington University School of Medicine, St Louis, MO; the Department of Mathematics and Statistics (CQ) and the Division of Geriatrics (DTV), University of New Mexico School of Medicine, Albuquerque, NM; and the Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM (DTV).
Dennis T VillarealFrom the Division of Endocrinology, University Campus Bio-Medico Di Roma, Rome, Italy (NN); the Division of Geriatrics and Aging, University of Rochester School of Medicine, Rochester, NY (KS); the Department of Preventive and Social Medicine, University of Otago, Dunedin School of Medicine, Dunedin, New Zealand (DLW); the Division of Geriatrics and Nutritional Science (DRS and DTV) and the Program in Physical Therapy (DRS), Washington University School of Medicine, St Louis, MO; the Department of Mathematics and Statistics (CQ) and the Division of Geriatrics (DTV), University of New Mexico School of Medicine, Albuquerque, NM; and the Section of Geriatrics, New Mexico VA Health Care System, Albuquerque, NM (DTV).
University of Otago · NZ

Funding

Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
TRANSGENICS COREP60DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 1986 to 2012
$25.2M
EXERCISE INTERVENTIONS DURING VOLUNTARY WEIGHT LOSS IN OBESE OLDER ADULTSR01AG031176 · NIA · WASHINGTON UNIVERSITY · PI VILLAREAL, DENNIS T. · 2009 to 2016
$2.3M
Weight Loss and Exercise in Frail Obese Elderly SubjectsR01AG025501 · NIA · WASHINGTON UNIVERSITY · PI VILLAREAL, DENNIS T. · 2005 to 2009
$1.7M
NCRR NIH HHS UL1-RR024992NIA NIH HHS AG031176NIA NIH HHS R01 AG025501NIA NIH HHS R01-AG025501NIA NIH HHS R01 AG031176NIDDK NIH HHS DK20579NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30-DK56341
6 · The paper itself

Abstract

backgroundObesity impairs cognition and health-related quality of life (HRQOL) in older adults; however, the appropriate treatment of obese older adults remains controversial.

objectiveThe objective was to determine the independent and combined effects of weight loss and exercise on cognition, mood, and HRQOL in obese older adults.

designOne hundred seven frail, obese older adults were randomly assigned to a control, weight-management (diet), exercise, or weight-management-plus-exercise (diet-exercise) group for 1 y. In this secondary analysis, main outcomes were Modified Mini-Mental State Examination (3MS) and total Impact of Weight on Quality of Life-Lite (IWQOL) scores. Other outcomes included Word Fluency Test, Trail Making Test Parts A and B, and Geriatric Depression Scale (GDS) scores.

resultsScores on the 3MS improved more in the diet (mean ± SE: 1.7 ± 0.4), exercise (2.8 ± 0.4), and diet-exercise (2.9 ± 0.4) groups than in the control group (0.1 ± 0.4) (between-group P = 0.0001-0.04); scores in the diet-exercise group improved more than in the diet group but not more than in the exercise group. Scores on the Word Fluency Test improved more in the exercise (4.1 ± 0.8) and diet-exercise (4.2 ± 0.7) groups than in the control group (-0.8 ± 0.8; both P = 0.001). For the Trail Making Test Part A, scores in the diet-exercise group (-11.8 ± 1.9) improved more than in the control group (-0.8 ± 1.9) (P = 0.001); a similar finding was observed for the Trail Making Test Part B. Scores on the IWQOL improved more in the diet (7.6 ± 1.6), exercise (10.1 ± 1.6), and diet-exercise (14.0 ± 1.4) groups than in the control group (0.3 ± 1.6) (P = 0.0001-0.03); scores in the diet-exercise group improved more than in the diet group but not more than in the exercise group. In the diet-exercise group, peak oxygen consumption and strength changes were independent predictors of 3MS changes; weight and strength changes were independent predictors of IWQOL changes. GDS scores did not change.

conclusionsWeight loss and exercise each improve cognition and HRQOL, but their combination may provide benefits similar to exercise alone. These findings could inform practice guidelines with regard to optimal treatment strategies for obese older adults. This trial was registered atclinicaltrials.govas NCT00146107.

Indexed as

CognitionExerciseQuality of LifeWeight LossActivities of Daily LivingAgedBlood GlucoseBody WeightEnergy IntakeFemaleHumansInflammationInsulin-Like Growth Factor IInsulin ResistanceLinear ModelsMaleBlood GlucoseInsulin-Like Growth Factor I

Identifiers

PMID24787497
PMCPMC4144098
OpenAlexW2162274622

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.