Evidence map›Paper›PMID 24787403›Full record

ArticleApplied optics2014

Synthesis of dye conjugates to visualize the cancer cells using fluorescence microscopy.

Yang Pu, Rui Tang, Jianpeng Xue, W B Wang, Baogang Xu, S Achilefu

Abstract read
In one paragraph

Article in Applied optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yang Pu
Rui Tang
Jianpeng Xue
W B Wang
Baogang Xu
S Achilefu

Funding

DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
FLUORESCENCE MOLECULAR TOMOGRAPHY SYSTEMS10OD020129 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2015
$330k
NCI NIH HHS R01 CA171651NIH HHS S10 OD020129NIH HHS S10 OD027042
6 · The paper itself

Abstract

The clinical diagnosis of most cancers is based on evaluation of histology microscopic slides to view the size and shape of cellular nuclei and morphological structure of tissue. To achieve this goal for in vivo and in-deep tissues, near infrared dyes-bovine serum albumin and immunoglobulin G conjugates were synthesized. The spectral study shows that the absorption and fluorescence of the dye conjugates are in the "tissue optical window" spectral ranges between 650 and 900 nm. The internalization and pinocytosis of the synthesized compounds were investigated at cell level using fluorescence microscopy to obtain the optimal concentration and staining time.

Indexed as

Contrast MediaFluorescent DyesHumansImage EnhancementImmunoglobulin GMCF-7 CellsMicroscopy, FluorescenceMolecular Diagnostic TechniquesNeoplasms, ExperimentalReproducibility of ResultsSensitivity and SpecificitySerum Albumin, BovineStaining and LabelingSubcellular FractionsContrast MediaFluorescent DyesImmunoglobulin GSerum Albumin, Bovine

Identifiers

PMID24787403
PMCPMC7328305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.