Evidence map›Paper›PMID 24786933›Full record

Trial reportEpidemiology and infection2015

Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children.

G Freeman, S Ng, R A P M Perera, V J Fang, D K M Ip, G M Leung, J S M Peiris, B J Cowling

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Epidemiology and infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Smoking and serological response to influenza vaccine.Human vaccines & immunotherapeutics · 2024
    Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G FreemanDivision of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
S NgDepartment of Ecology and Evolutionary Biology,Princeton University,Princeton, NJ,USA.
R A P M PereraDivision of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
V J FangDivision of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
D K M IpDivision of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
G M LeungDivision of Community Medicine and Public Health Practice, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
J S M PeirisDivision of Public Health Laboratory Sciences, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.
B J CowlingDivision of Epidemiology and Biostatistics, School of Public Health, Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong Special Administrative Region,China.

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
NIGMS NIH HHS U54 GM088558
6 · The paper itself

Abstract

We examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations.

Indexed as

AdolescentAntibodies, ViralChildFemaleHemagglutination Inhibition TestsHong KongHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza, HumanInfluenza VaccinesMaleMultivariate AnalysisVaccines, InactivatedAntibodies, ViralInfluenza VaccinesVaccines, InactivatedImmunization (vaccination)influenzaserologystatistics

Identifiers

PMID24786933
PMCPMC4887284

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.