ArticleEpidemiology and infection2014
Next-generation sequencing of southern African Crimean-Congo haemorrhagic fever virus isolates reveals a high frequency of M segment reassortment.
Article in Epidemiology and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Genomic characterization of Crimean-Congo hemorrhagic fever virus in Hyalomma ticks from Cameroon highlights circulation of the Africa 3 lineage.Parasites & vectors · 2026Article
- Widespread circulation of Crimean-Congo haemorrhagic fever virus in ticks, Corsica (France), 2024.One health (Amsterdam, Netherlands) · 2026Article
- Integrated surveillance, virus isolation and phylogenetic characterization of Crimean-Congo hemorrhagic fever virus in Central Kazakhstan.Frontiers in veterinary science · 2026Article
- Review
- Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virus (CCHFV) and Hazara Virus (HAZV).Medical microbiology and immunology · 2024Article
- Purification and characterization of soluble recombinant Crimean-Congo hemorrhagic fever virus glycoprotein Gc expressed in mammalian 293F cells.BMC biotechnology · 2024Article
- Crimean-Congo Hemorrhagic Fever Virus Diversity and Reassortment, Pakistan, 2017-2020.Emerging infectious diseases · 2024Article
- Article
- A Novel RT-LAMP for the Detection of Different Genotypes of Crimean-Congo Haemorrhagic Fever Virus in Patients from Spain.International journal of molecular sciences · 2023Article
- First Whole Genome Sequencing of Crimean-Congo Hemorrhagic Fever Virus (CCHFV) in Tick Species within Ghana.Transboundary and emerging diseases · 2023Article
- Cryo-EM structure of glycoprotein C from Crimean-Congo hemorrhagic fever virus.Virologica Sinica · 2022Article
- Role of Anopheles Mosquitoes in Cache Valley Virus Lineage Displacement, New York, USA.Emerging infectious diseases · 2022Article
- Serologic and molecular evidence for circulation of Crimean-Congo hemorrhagic fever virus in ticks and cattle in Zambia.PLoS neglected tropical diseases · 2021Article
- Widespread Detection of Multiple Strains of Crimean-Congo Hemorrhagic Fever Virus in Ticks, Spain.Emerging infectious diseases · 2021Article
- Reassortment events in the evolution of hantaviruses.Virus genes · 2018Review
- Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge.PLoS neglected tropical diseases · 2018Article
- Long-lived CD8+ T cell responses following Crimean-Congo haemorrhagic fever virus infection.PLoS neglected tropical diseases · 2017Article
- Identification of broadly neutralizing monoclonal antibodies against Crimean-Congo hemorrhagic fever virus.Antiviral research · 2017Article
- Transstadial Transmission and Long-term Association of Crimean-Congo Hemorrhagic Fever Virus in Ticks Shapes Genome Plasticity.Scientific reports · 2016Article
- Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crimean Congo haemorrhagic fever virus (CCHFV) is a bunyavirus with a single-stranded RNA genome consisting of three segments (S, M, L), coding for the nucleocapsid protein, envelope glycoproteins and RNA polymerase, respectively. To date only five complete genome sequences are available from southern African isolates. Complete genome sequences were generated for 10 southern African CCHFV isolates using next-generation sequencing techniques. The maximum-likelihood method was used to generate tree topologies for 15 southern African plus 26 geographically distinct complete sequences from GenBank. M segment reassortment was identified in 10/15 southern African isolates by incongruencies in grouping compared to the S and L segments. These reassortant M segments cluster with isolates from Asia/Middle East, while the S and L segments cluster with strains from South/West Africa. The CCHFV M segment shows a high level of genetic diversity, while the S and L segments appear to co-evolve. The reason for the high frequency of M segment reassortment is not known. It has previously been suggested that M segment reassortment results in a virus with high fitness but a clear role in increased pathogenicity has yet to be shown.
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