Evidence map›Paper›PMID 24786605›Full record

Trial reportBritish journal of cancer2014

Diabetes and pancreatic cancer survival: a prospective cohort-based study.

A T Toriola, R Stolzenberg-Solomon, L Dalidowitz, D Linehan, G Colditz

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  13. Survival and prognostic factors among hospitalized pancreatic cancer patients in northwestern Iran.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

A T ToriolaDepartment of Surgery, Division of Public Health Sciences, Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8100, St Louis, MO 63144, USA.
R Stolzenberg-SolomonBranch of Nutritional Epidemiology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, Room 6E420, Rockville, MD 20850, USA.
L DalidowitzDepartment of Surgery, Division of Public Health Sciences, Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8100, St Louis, MO 63144, USA.
D LinehanDepartment of Surgery, Section of Hepato-Pancreatico-Biliary and Gastrointestinal Surgery, Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8100, St Louis, MO 63144, USA.
G ColditzDepartment of Surgery, Division of Public Health Sciences, Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8100, St Louis, MO 63144, USA.
Washington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes is a risk factor for pancreatic cancer but its association with survival from pancreatic cancer is poorly understood. Our objective was to investigate the association of diabetes with survival among pancreatic cancer patients in a prospective cohort-based study where diabetes history was ascertained before pancreatic cancer diagnosis.

methodsWe evaluated survival by baseline (1993-2001) self-reported diabetes history (n=62) among 504 participants that developed exocrine pancreatic cancer within the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using Cox proportional hazards model, adjusted for age, sex, body mass index, race, smoking, and tumour stage (local, locally advanced, and metastatic).

resultsThe multivariable-adjusted HR for mortality comparing participants with diabetes to those without was 1.52 (95% CI=1.14-2.04, P-value <0.01). After excluding those diagnosed with pancreatic cancer within 3 years of study enrolment, HR for mortality among those with diabetes was 1.45 (95% CI=1.06-2.00, P-value=0.02).

conclusionsUsing prospectively collected data, our findings indicate that diabetes is associated with worse survival among patients with pancreatic cancer.

Indexed as

AgedCohort StudiesDiabetes MellitusEarly Detection of CancerFemaleHumansMaleMiddle AgedPancreatic NeoplasmsProportional Hazards ModelsProspective StudiesRisk FactorsSurvival AnalysisUnited States

Identifiers

PMID24786605
PMCPMC4090724
OpenAlexW1979234711

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.