ArticleJournal of perinatology : official journal of the California Perinatal Association2014
Chorioamnionitis: epidemiology of newborn management and outcome United States 2008.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Meconium-stained amniotic fluid.American journal of obstetrics and gynecology · 2023Pooled it
- Incidence of maternal peripartum infection: A systematic review and meta-analysis.PLoS medicine · 2019Pooled it
- Clinical chorioamnionitis at term: the amniotic fluid fatty acyl lipidome.Journal of lipid research · 2016Trial
- Predictors of Severe Histological Chorioamnionitis and Associated Neonatal Outcomes in Term Intrapartum Clinical Chorioamnionitis: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Maternal and Microbiological Outcomes in GBS-Positive Patients Receiving Intrapartum Ampicillin versus Clindamycin: A Retrospective Cohort Study.Gynecologic and obstetric investigation · 2026Article
- Survival Status and Predictors of Mortality Among Preterm Neonates Admitted to the Neonatal Intensive Care Units in Central Ethiopia: A Prospective Follow-Up Study.Public health challenges · 2025Article
- Maternal Obesity and Neonatal Death in Preterm US Pacific Islander Neonates Using 2 Analytic Approaches.JAMA network open · 2025Article
- Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19.Pediatric research · 2024Article
- Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.American journal of obstetrics and gynecology · 2024Review
- The Association between Term Chorioamnionitis during Labor and Long-Term Infectious Morbidity of the Offspring.Journal of clinical medicine · 2024Article
- Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Placental clearance not synthesis tempers exaggerated pro-inflammatory cytokine response in neonates exposed to chorioamnionitis.Pediatric research · 2023Article
- Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania.Medicina (Kaunas, Lithuania) · 2022Article
- Management of clinical chorioamnionitis: an evidence-based approach.American journal of obstetrics and gynecology · 2020Review
- Interaction of chorioamnionitis at term with maternal, fetal and obstetrical factors as predictors of neonatal mortality: a population-based cohort study.BMC pregnancy and childbirth · 2020Article
- Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes.Journal of perinatal medicine · 2020Article
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- Management of Late Preterm and Term Neonates exposed to maternal Chorioamnionitis.BMC pediatrics · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCurrent American Academy of Pediatric recommendations call for the empirical use of antibiotics for all well-appearing term newborn infants born to women given a diagnosis of chorioamnionitis. The objective of this analysis was to determine among term infants (37-42 weeks gestation) the prevalence of exposure to clinical chorioamnionitis, intrapartum antibiotics, infant antibiotic use and neonatal intensive care unit (NICU) admission and the relationship of these risk factors to neonatal mortality. STUDY
designUnited States-linked infant birth and death certificate files for the year 2008 were used. Maternal demographic variables, labor and delivery risk factors and infant characteristics were analyzed for associations with a reported diagnosis of chorioamnionitis and neonatal death, NICU admission and antibiotic usage.
resultThere were 2,281,386 births available with information on the diagnosis of chorioamnionitis. The prevalence of chorioamnionitis in this population was 9.7 per 1000 live births (LB) and the neonatal mortality rate for exposed infants was 1.40/1000 LB vs 0.81/1000 LB for infants without chorioamnionitis, odds ratio (OR)=1.72, 95% confidence interval 1.20-2.45. The OR for neonatal death for infants with chorioamnionitis exposure who received antibiotics vs those who did not was 0.69 (95% confidence interval=0.21-2.26).
conclusionExposure to chorioamnionitis is associated with an increased risk of neonatal mortality. Guidelines for treatment of infants exposed to chorioamnionitis with antibiotics are followed in only a small proportion of such cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.