ArticlePLoS genetics2014
Heterogeneity in the frequency and characteristics of homologous recombination in pneumococcal evolution.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 84 citations in OpenAlex.
- Lineage-specific variation in frequency and hotspots of recombination in invasive Escherichia coli.BMC genomics · 2025Article
- Genome-wide transformation reveals extensive exchange across closely related Bacillus species.Nucleic acids research · 2023Article
- Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae.Nucleic acids research · 2023Article
- Recombination as an enforcement mechanism of prosocial behavior in cooperating bacteria.iScience · 2023Article
- Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species.Communications biology · 2023Article
- Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA.Genome medicine · 2022Article
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- Neuroprotective effects of CysLTR antagonist onExperimental and therapeutic medicine · 2022Article
- Frequencies and characteristics of genome-wide recombination in Streptococcus agalactiae, Streptococcus pyogenes, and Streptococcus suis.Scientific reports · 2022Article
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- Nasopharyngeal carriage of Streptococcus pneumoniae among healthy children in Kassena-Nankana districts of Northern Ghana.BMC infectious diseases · 2021Article
- Genome-Wide Analysis of the Temporal Genetic Changes inMicroorganisms · 2021Article
- Genomic Epidemiology and Evolution of Diverse Lineages of Clinical Campylobacter jejuni Cocirculating in New Hampshire, USA, 2017.Journal of clinical microbiology · 2020Article
- Article
- Designing ecologically optimized pneumococcal vaccines using population genomics.Nature microbiology · 2020Article
- Distinct but Intertwined Evolutionary Histories of Multiple Salmonella enterica Subspecies.mSystems · 2020Article
- Genetic Structure, Function, and Evolution of Capsule Biosynthesis Loci inFrontiers in microbiology · 2020Article
- A Hopeful Sea-Monster: A Very Large Homologous Recombination Event Impacting the Core Genome of the Marine PathogenFrontiers in microbiology · 2020Article
- Comparative Virulence and Genomic Analysis ofFrontiers in microbiology · 2020Article
- Multiplex gene transfer by genetic transformation between isolated S. pneumoniae cells confined in microfluidic droplets.Integrative biology : quantitative biosciences from nano to macro · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The bacterium Streptococcus pneumoniae (pneumococcus) is one of the most important human bacterial pathogens, and a leading cause of morbidity and mortality worldwide. The pneumococcus is also known for undergoing extensive homologous recombination via transformation with exogenous DNA. It has been shown that recombination has a major impact on the evolution of the pathogen, including acquisition of antibiotic resistance and serotype-switching. Nevertheless, the mechanism and the rates of recombination in an epidemiological context remain poorly understood. Here, we proposed several mathematical models to describe the rate and size of recombination in the evolutionary history of two very distinct pneumococcal lineages, PMEN1 and CC180. We found that, in both lineages, the process of homologous recombination was best described by a heterogeneous model of recombination with single, short, frequent replacements, which we call micro-recombinations, and rarer, multi-fragment, saltational replacements, which we call macro-recombinations. Macro-recombination was associated with major phenotypic changes, including serotype-switching events, and thus was a major driver of the diversification of the pathogen. We critically evaluate biological and epidemiological processes that could give rise to the micro-recombination and macro-recombination processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.