Evidence map›Paper›PMID 24786172›Full record

ReviewScandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society2014

Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research.

E Gonzalez, E E Moore, H B Moore, M P Chapman, C C Silliman, A Banerjee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 90 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Thromboelastometric Monitoring of the Hemostatic Effect of Platelet Concentrates Transfusion in Thrombocytopenic Children Undergoing Chemotherapy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2015
    Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Hemostatic Balance in Severe Trauma.Frontiers in pediatrics · 2020
    Review
  13. Bloodletting Puncture at Hand TwelveFrontiers in neuroscience · 2020
    Article
  14. Article
  15. Article
  16. ClotChip: A Microfluidic Dielectric Sensor for Point-of-Care Assessment of Hemostasis.IEEE transactions on biomedical circuits and systems · 2017
    Article
  17. Progresses in understanding trauma-induced coagulopathy and the underlying mechanism.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2017
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

E GonzalezTrauma Research Center, Department of Surgery, University of Colorado, Denver, CO, USA Department of Surgery, Denver Health Medical Center, Denver, CO, USA.
E E MooreTrauma Research Center, Department of Surgery, University of Colorado, Denver, CO, USA Department of Surgery, Denver Health Medical Center, Denver, CO, USA Ernest.Moore@dhha.org.
H B MooreTrauma Research Center, Department of Surgery, University of Colorado, Denver, CO, USA Department of Surgery, Denver Health Medical Center, Denver, CO, USA.
M P ChapmanTrauma Research Center, Department of Surgery, University of Colorado, Denver, CO, USA.
C C SillimanTrauma Research Center, Department of Surgery, University of Colorado, Denver, CO, USA Department of Pediatrics, University of Colorado, Denver, CO, USA Department of Research, Bonfils Blood Center, Denver, CO, USA.
A BanerjeeTrauma Research Center, Department of Surgery, University of Colorado, Denver, CO, USA.
University of Colorado Denver · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Trauma Reprograms CellsP50GM049222 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI BANERJEE, ANIRBAN · 1993 to 2017
$26.1M
Mechanisms of Trauma-Induced CoagulopathyT32GM008315 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Mitchell Cohen, ELIZABETH J. KOVACS · 1991 to 2026
$7.1M
NCATS NIH HHS UL1 TR001082NIGMS NIH HHS P50 GM049222NIGMS NIH HHS T32 GM008315
6 · The paper itself

Abstract

introductionInjury is the second leading cause of death worldwide, and as much as 40% of injury-related mortality is attributed to uncontrollable hemorrhage. This persists despite establishment of regionalized trauma systems and advances in the management of severely injured patients. Trauma-induced coagulopathy has been identified as the most common preventable cause of postinjury mortality.

methodsA review of the current literature was performed by collecting PUBMED references related to trauma-induced coagulopathy. Data were then critically analyzed and summarized based on the authors' clinical and research perspective, as well as that reported by other institutions and researchers interested in trauma-induced coagulopathy. A particular focus was placed on those aspects of coagulopathy in which agreement among clinical and basic scientists is currently lacking; these include, pathophysiology, the role of blood components and factor therapy, and goal-directed assessment and management.

resultsTrauma-induced coagulopathy has been recognized in approximately one-third of trauma patients. There is a vast range of severity, and the emergence of viscoelastic assays, such as thrombelastography and rotational thromboelastogram, has refined its diagnosis and management, particularly through the establishment of goal-directed massive transfusion protocols. Despite advancements in the diagnosis and management of trauma-induced coagulopathy, much remains to be understood regarding its pathophysiology. The cell-based model of hemostasis has allowed for characterization of endothelial dysfunction, impaired thrombin generation, platelet dysfunction, fibrinolysis, endogenous anticoagulants such as protein-C, and antifibrinolytic proteins. These concepts collectively compose the contemporary, but still partial, understanding of trauma-induced coagulopathy.

conclusionTrauma-induced coagulopathy is a complex pathophysiological condition, of which some mechanisms have been characterized, but much remains to be understood in order to translate this knowledge into improved outcomes for the injured patient.

Indexed as

CoagulopathyfibrinolysishemorrhageROTEMthrombelastographytransfusiontrauma

Identifiers

PMID24786172
PMCPMC4214916
OpenAlexW2112657827

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.