Evidence map›Paper›PMID 24785976›Full record

ArticleJournal of human hypertension2015

Reduction of plasma aldosterone and arterial stiffness in obese pre- and stage1 hypertensive subjects after aerobic exercise.

S R Collier, K Sandberg, A M Moody, V Frechette, C D Curry, H Ji, R Gowdar, D Chaudhuri, M Meucci

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

S R CollierVascular Biology and Autonomic Studies Laboratory, Department of Health Leisure and Exercise Science, Appalachian State University, Boone, NC, USA.
K SandbergCenter for the Study of Sex Differences in Health, Aging and Disease, Department of Medicine, Georgetown University Medical Center, Washington DC, USA.
A M MoodyVascular Biology and Autonomic Studies Laboratory, Department of Health Leisure and Exercise Science, Appalachian State University, Boone, NC, USA.
V FrechetteDepartment of Medicine, Upstate Medical University, Syracuse, NY, USA.
C D CurryVascular Biology and Autonomic Studies Laboratory, Department of Health Leisure and Exercise Science, Appalachian State University, Boone, NC, USA.
H JiCenter for the Study of Sex Differences in Health, Aging and Disease, Department of Medicine, Georgetown University Medical Center, Washington DC, USA.
R GowdarDepartment of Medicine, Upstate Medical University, Syracuse, NY, USA.
D ChaudhuriDepartment of Medicine, Upstate Medical University, Syracuse, NY, USA.
M MeucciDepartment of Movement, University of Rome 'Foro Italico', Human and Health Sciences, Rome, Italy.
SUNY Upstate Medical University · US

Funding

Immune Modulation of HypertensionR01HL119380 · NHLBI · GEORGETOWN UNIVERSITY · PI SANDBERG, KATHRYN L · 2015 to 2018
$2.4M
NHLBI NIH HHS R01 HL119380
6 · The paper itself

Abstract

Obesity-related hypertension is associated with increased activity of the renin-angiotensin-aldosterone system (RAAS), increasing arterial stiffness. Aerobic exercise decreases pulse wave velocity (PWV), therefore a treatment option for hypertension and obesity. Assess RAAS activity and PWV before and after 4 weeks of aerobic training in unmedicated, pre-to-stage-1 hypertensives. Ten obese subjects (52±3.2 years, body mass index=33.5±1.4) performed 30 min of aerobic exercise on a treadmill 3 days per week at 65% of peak oxygen consumption (VO2peak). Descriptive characteristics, systolic and diastolic blood pressure (SBP and DBP), PWV, and a blood draw was performed at baseline, following the 4-week control and training interventions. No differences in descriptive characteristics during the control period were observed, however, a significant decrease in plasma aldosterone (ALDO) (255.4±75 to 215.8±66 pg ml(-1), P=0.001), SBP (140±12 to 136±10.4 mm Hg; P=0.02), DBP (89±4.2 to 85±6.3 mm Hg; P=0.03) and central PWV (11.2±0.6 to 9.8±0.8 m s(-1); P=0.04) was shown pre-to-post exercise training. Four weeks of moderate-intensity aerobic training in obese, hypertensives decreases plasma ALDO independently of body weight and is significantly correlated to decreases in PWV reductions.

Indexed as

Exercise TherapyVascular StiffnessAldosteroneBiomarkersBlood PressureDown-RegulationFemaleHumansHypertensionMaleMiddle AgedObesityOxygen ConsumptionPrehypertensionProspective StudiesPulse Wave AnalysisAldosteroneBiomarkers

Identifiers

PMID24785976
PMCPMC5350632
OpenAlexW1980023671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.