ArticleJournal of human genetics2014
The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population.
Article in Journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- DNA methylation in peripheral tissues and left-handedness.Scientific reports · 2022Pooled it
- A decade of progress in understanding LRRTM and Slitrk synaptic cell-adhesion molecules.Molecules and cells · 2026Review
- Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence.World journal of psychiatry · 2026Review
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.Nature communications · 2023Article
- Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.eLife · 2022Article
- Polygenic scores for handedness and their association with asymmetries in brain structure.Brain structure & function · 2022Article
- Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus.Molecular psychiatry · 2021Article
- Synaptic recognition molecules in development and disease.Current topics in developmental biology · 2021Article
- Human Lateralization, Maternal Effects and Neurodevelopmental Disorders.Frontiers in behavioral neuroscience · 2021Article
- Quantitative In vivo MRI Assessment of Structural Asymmetries and Sexual Dimorphism of Transient Fetal Compartments in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Targeted sequencing of the LRRTM gene family in suicide attempters with bipolar disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- DNA methylation of dopamine-related gene promoters is associated with line bisection deviation in healthy adults.Scientific reports · 2019Article
- Building an Asymmetrical Brain: The Molecular Perspective.Frontiers in psychology · 2019Review
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Article
- Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries.eLife · 2017Article
- Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults.Molecular neurobiology · 2016Article
- Genetic Consideration of Schizotypal Traits: A Review.Frontiers in psychology · 2016Review
- Control of neural circuit formation by leucine-rich repeat proteins.Trends in neurosciences · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imprinted genes have been posited to have important roles in human brain development and cognition, but their effects in nonclinical populations have yet to be investigated. Single-nucleotide polymorphisms (SNPs) of the imprinted gene LRRTM1 have previously been associated with schizophrenia risk and with handedness in individuals with dyslexia. We tested the hypothesis that genetic variation (SNPs) and epigenetic variation (methylation) in this gene are associated with schizotypy and handedness in a nonclinical population. Risk alleles of the three schizophrenia-linked SNPs were associated with significantly and substantially higher levels of total schizotypy. Variation in SNP genotypes was not associated with handedness, but levels of methylation in a block of CpG sites in the putative LRRTM1 promoter region were associated with more-mixed handedness. These findings provide evidence of continuity between schizophrenia and schizotypy with regard to the psychological effects of allelic variation in this imprinted gene, and show that epigenetic variation in an imprinted gene mediates the development and expression of human handedness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.