ArticleThe Journal of cell biology1989
Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes.
Article in The Journal of cell biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Down-regulation of ERK1 and ERK2 activity during differentiation of the intestinal cell line HT-29.Molecular and cellular biochemistry · 2002Article
- Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium.The Journal of cell biology · 2000Article
- Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells.The Journal of cell biology · 1997Article
- LI-cadherin-mediated cell-cell adhesion does not require cytoplasmic interactions.The Journal of cell biology · 1997Article
- Transforming growth factor-alpha increases tyrosine phosphorylation of microtubule-associated protein kinase in a small intestinal crypt cell line (IEC-6).The Biochemical journal · 1994Article
- Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ.The Journal of cell biology · 1994Article
- Golgi-derived vesicles from developing epithelial cells bind actin filaments and possess myosin-I as a cytoplasmically oriented peripheral membrane protein.The Journal of cell biology · 1993Article
- c-src structure in human cancers with elevated pp60c-src activity.British journal of cancer · 1991Article
- Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Growth and differentiation of stem cells is thought to be regulated by growth factors and responding protein tyrosine kinase activities. Comparing mitotic stem cells from the adult intestinal epithelium, isolated from the crypts of Lieberkuhn, with isolated differentiated absorbtive cells we find major differences in the levels of phosphotyrosine-containing proteins. Crypt stem cells possess two major phosphotyrosine-containing polypeptides of 36 and 17 kD which have greater than 15 times more phosphotyrosine than that present in the polypeptides of differentiated enterocytes. Tyrosine kinase activity and similar phosphotyrosine-containing proteins are associated with the Triton cytoskeleton. Moreover, crypt tyrosine kinase(s) is active in vitro in phosphorylating similar cytoskeleton-associated substrates. These results suggest that cytoskeleton-associated phosphotyrosine kinase(s) and their substrates may play a role in growth and differentiation of adult intestinal epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.