Evidence map›Paper›PMID 24784986›Full record

ArticleBiodemography and social biology2014

Validation of blood-based assays using dried blood spots for use in large population studies.

Eileen Crimmins, Jung Ki Kim, Heather McCreath, Jessica Faul, David Weir, Teresa Seeman

Abstract read
In one paragraph

Article in Biodemography and social biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025
    Pooled it
  2. Trial
  3. Article
  4. Work-Influenced Circadian Disruption Connected to Disease Risk but Not Microbiomes in a Cohort of Philadelphia Nurses.American journal of human biology : the official journal of the Human Biology Council · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Dried blood spot based biomarkers in the Health and Retirement Study: 2006 to 2016.American journal of human biology : the official journal of the Human Biology Council · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eileen Crimminsa Davis School of Gerontology , University of Southern California , Los Angeles , California , USA.
Jung Ki Kim
Heather McCreath
Jessica Faul
David Weir
Teresa Seeman

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
Network on Measurement of Biological RiskR24AG037898 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M, SEEMAN, TERESA E · 2010 to 2014
$1.1M
NIA NIH HHS P30 AG017265NIA NIH HHS P30 AG17265NIA NIH HHS R24 AG037898NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

Assessment of health in large population studies has increasingly incorporated measures of blood-based biomarkers based on the use of dried blood spots (DBS). The validity of DBS assessments made by labs used by large studies is addressed by comparing assay values from DBS collected using conditions similar to those used in the field with values from whole blood samples. The DBS approach generates values that are strongly related to whole blood levels of HbA1c, cystatin C, and C-reactive protein. Assessing lipid levels reliably with DBS appears to be a greater challenge. However, even when DBS values and values from venous blood are highly correlated, they are often on a different scale, and using conventional cutoffs may be misleading.

Indexed as

BiomarkersCholesterolCholesterol, HDLC-Reactive ProteinCystatin CDried Blood Spot TestingGlycated HemoglobinHumansMiddle AgedReference ValuesReproducibility of ResultsBiomarkersCholesterolCholesterol, HDLC-Reactive ProteinCystatin CGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID24784986
PMCPMC4117354

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.