Evidence map›Paper›PMID 24784829›Full record

ArticleDiabetes care2014

Depressive symptoms, antidepressant use, and the incidence of diabetes in the Black Women's Health Study.

Varsha G Vimalananda, Julie R Palmer, Hanna Gerlovin, Lauren A Wise, James L Rosenzweig, Lynn Rosenberg, Edward A Ruiz-Narváez

Abstract read
In one paragraph

Article in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Predictors of Health-Related Quality of Life Among African American Men.Journal of racial and ethnic health disparities · 2022
    Article
  4. Article
  5. Article
  6. Comparing anxiety and depression to obesity and smoking as predictors of major medical illnesses and somatic symptoms.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019
    Article
  7. Impact of Muscarinic MCNS drugs · 2017
    Article
  8. Article
  9. Depression among Middle-aged Persons.Osong public health and research perspectives · 2017
    Article
  10. Observational
  11. Parental History of Diabetes, Positive Affect, and Diabetes Risk in Adults: Findings from MIDUS.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016
    Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Varsha G VimalanandaSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA varshav@bu.edu.
Julie R PalmerSlone Epidemiology Center, Boston University, Boston, MADepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
Hanna GerlovinSlone Epidemiology Center, Boston University, Boston, MADepartment of Biostatistics, Boston University School of Public Health, Boston, MA.
Lauren A WiseSlone Epidemiology Center, Boston University, Boston, MADepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
James L RosenzweigSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA.
Lynn RosenbergSlone Epidemiology Center, Boston University, Boston, MADepartment of Epidemiology, Boston University School of Public Health, Boston, MA.
Edward A Ruiz-NarváezSlone Epidemiology Center, Boston University, Boston, MADepartment of Epidemiology, Boston University School of Public Health, Boston, MA.

Funding

FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
A Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7M
Weight gain, type 2 diabetes, and factors that affect neuroendocrine functionR01MD007015 · NIMHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2016
$1.4M
NCI NIH HHS R01 CA058420NCI NIH HHS R01-CA-058420NCI NIH HHS UM1 CA164974NIMHD NIH HHS R01 MD007015NIMHD NIH HHS R01-MD-007015
6 · The paper itself

Abstract

objectiveTo assess the relationship of depressive symptoms and use of antidepressants with incident type 2 diabetes in prospective data from a large cohort of U.S. African American women. RESEARCH DESIGN AND

methodsThe Black Women's Health Study (BWHS) is an ongoing prospective cohort study. We followed 35,898 women from 1999 through 2011 who were without a diagnosis of diabetes and who had completed the Center for Epidemiologic Studies Depression Scale (CES-D) in 1999. CES-D scores were categorized as <16, 16-22, 23-32, and ≥33, which reflected increasingly more depressive symptoms. We estimated incidence rate ratios (IRRs) and 95% CIs for incident diabetes using Cox proportional hazards models. The basic multivariable model included age, time period, family history of diabetes, and education. In further models, we controlled for lifestyle factors and BMI. We also assessed the association of antidepressant use with incident diabetes.

resultsOver 12 years of follow-up, there were 3,372 incident diabetes cases. Relative to CES-D score <16, IRRs (95% CI) of diabetes for CES-D scores 16-22, 23-32, and ≥33 were 1.23 (1.12-1.35), 1.26 (1.12-1.41), and 1.45 (1.24-1.69), respectively, in the basic multivariate model. Multiple adjustment for lifestyle factors and BMI attenuated the IRRs to 1.11 (1.01-1.22), 1.08 (0.96-1.22), and 1.22 (1.04-1.43). The adjusted IRR for antidepressant use was 1.26 (1.11-1.43). Results were similar among obese women.

conclusionsBoth depressive symptoms and antidepressant use are associated with incident diabetes among African American women. These associations are mediated in part, but not entirely, through lifestyle factors and BMI.

Indexed as

AdultAntidepressive AgentsAttitude to HealthBlack or African AmericanCohort StudiesComorbidityDepressionDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansIncidenceLife StyleMiddle AgedObesityProportional Hazards ModelsAntidepressive Agents

Identifiers

PMID24784829
PMCPMC4113175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.