ArticleTissue engineering. Part A2014
Improvement of bone regeneration capability of ceramic scaffolds by accelerated release of their calcium ions.
Article in Tissue engineering. Part A, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery.Annals of biomedical engineering · 2017Pooled it
- Scaffold Design: A Review of Material and Immune Modulation in Bone Tissue Engineering.Cell and tissue banking · 2026Review
- Engineered 3D mesenchymal stem cell aggregates with multifunctional prowess for bone regeneration: Current status and future prospects.Journal of advanced research · 2026Review
- Synergistic integration of biomaterials in orthopedic implantation for infection preventing and tissue engineering.Regenerative biomaterials · 2026Review
- Animal Experimental Study on Delayed Implantation in a Severely Atrophic Alveolar Ridge Reconstructed Using a 3D-Printed Bioactive Glass Scaffold: A Pilot Study.Journal of functional biomaterials · 2025Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Enhanced Release of Calcium Ions from Hydroxyapatite Nanoparticles with an Increase in Their Specific Surface Area.Materials (Basel, Switzerland) · 2023Article
- Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model.Regenerative therapy · 2023Article
- Electrical Stimulation Therapy and HA/TCP Composite Scaffolds Modulate the Wnt Pathways in Bone Regeneration of Critical-Sized Defects.Bioengineering (Basel, Switzerland) · 2023Article
- [Synthetic bone replacement substances].Orthopadie (Heidelberg, Germany) · 2022Article
- Hybprinting for musculoskeletal tissue engineering.iScience · 2022Review
- Cytocompatibility and Bioactive Ion Release Profiles of Phosphoserine Bone Adhesive: Bridge from In Vitro to In Vivo.Biomedicines · 2022Article
- Functionalization of Synthetic Bone Substitutes.International journal of molecular sciences · 2021Review
- Laser Additively Manufactured Iron-Based Biocomposite: Microstructure, Degradation, andFrontiers in bioengineering and biotechnology · 2021Article
- Multimaterial Segmented Fiber Printing for Gradient Tissue Engineering.Tissue engineering. Part C, Methods · 2019Article
- Comparison of the osteogenic capability of rat bone mesenchymal stem cells on collagen, collagen/hydroxyapatite, hydroxyapatite and biphasic calcium phosphate.Regenerative biomaterials · 2018Article
- Four-Dimensional Printing Hierarchy Scaffolds with Highly Biocompatible Smart Polymers for Tissue Engineering Applications.Tissue engineering. Part C, Methods · 2016Article
- Osteoinductive PolyHIPE Foams as Injectable Bone Grafts.Tissue engineering. Part A · 2016Article
- A Comparative Study of the Sintering Behavior of Pure and Manganese-Substituted Hydroxyapatite.Materials (Basel, Switzerland) · 2015Article
- Mineralized collagen scaffolds induce hMSC osteogenesis and matrix remodeling.Biomaterials science · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To regenerate the bone tissue, the fabrication of scaffolds for better tissue regeneration has attracted a great deal of attention. In fact, growth factors are already used in clinical practice and are being investigated for enhancing the capacity for bone tissue regeneration. However, despite their strong osteoinductive activity, these growth factors have several limitations: safety issues, high treatment costs, and the potential for ectopic bone formation. The aim of this study was therefore to develop ceramic scaffolds that could promote the capacity for bone regeneration without growth factors. Three-dimensional ceramic scaffolds were successfully fabricated from hydroxyapatite (HA) and tricalcium phosphate (TCP) using projection-based microstereolithography, which is an additive manufacturing technology. The effects of calcium ions released from ceramic scaffolds on osteogenic differentiation and bone regeneration were evaluated in vitro and in vivo. The osteogenesis-related gene expression and area of new bone formation in the HA/TCP scaffolds was higher than those in the HA scaffolds. Moreover, regenerated bone tissue in HA/TCP scaffolds were more matured than that in HA scaffolds. Through this study, we were able to enhance the bone regeneration capacity of scaffolds not by growth factors but by calcium ions released from the scaffolds. Ceramic scaffolds developed in this study might be useful for enhancing the capacity for regeneration in complex bone defects.
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