ArticlePlant physiology2014
A UDP-Glucose:Monoterpenol Glucosyltransferase Adds to the Chemical Diversity of the Grapevine Metabolome.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 126 citations in OpenAlex.
- Integrated omics identifies VviGTs and VviMYB174 as drivers of glycosylated monoterpenoid accumulation in 'Ruiduhongyu' grapes.Horticulture research · 2026Article
- A Metabolome Atlas of Grape Biodiversity.Journal of agricultural and food chemistry · 2026Article
- Genetic blueprint of herbaceous peony floral scent: evidence from terpene synthase, Nudix hydrolase, and prenyltransferase.Horticulture research · 2026Article
- Article
- Unveiling the catalytical roles of three glycosyltransferases in triterpenoid saponins in quinoa.Plant biotechnology journal · 2025Article
- Transcription Profiling of Glycosyltransferases inJournal of agricultural and food chemistry · 2025Article
- GWAS identifies a molecular marker cluster associated with monoterpenoids in grapes.Horticulture research · 2025Article
- Engineering terpene synthases and their substrates for the biocatalytic production of terpene natural products and analogues.Chemical communications (Cambridge, England) · 2025Review
- Genome-wide characterization of Solanum tuberosum UGT gene family and functional analysis of StUGT178 in salt tolerance.BMC genomics · 2024Article
- Chemical and Transcriptomic Analyses Provide New Insights into Key Genes for Ginsenoside Biosynthesis in the Rhizome ofMolecules (Basel, Switzerland) · 2024Article
- Integrated Transcriptomic and Metabolomic Analysis Revealed Abscisic Acid-Induced Regulation of Monoterpene Biosynthesis in Grape Berries.Plants (Basel, Switzerland) · 2024Article
- Identification and Functional Verification of the Glycosyltransferase Gene Family Involved in Flavonoid Synthesis inPlants (Basel, Switzerland) · 2024Article
- Vineyard microclimate alterations induced by black inter-row mulch through transcriptome reshaped the flavoromics of cabernet sauvignon grapes.BMC plant biology · 2024Article
- Genome-wide investigation of UDP-Glycosyltransferase family in Tartary buckwheat (Fagopyrum tataricum).BMC plant biology · 2024Article
- Ethylene-responsive VviERF003 modulates glycosylated monoterpenoid synthesis by upregulatingHorticulture research · 2024Article
- Cytochrome P450 VvCYP76F14 dominates the production of wine bouquet precursors in wine grapes.Frontiers in plant science · 2024Article
- Characterization of UGT71, a major glycosyltransferase family for triterpenoids, flavonoids and phytohormones-biosynthetic in plants.Forestry research · 2024Review
- Article
- The terpene synthase (TPS) gene family in kiwifruit shows high functional redundancy and a subset of TPS likely fulfil overlapping functions in fruit flavour, floral bouquet and defence.Molecular horticulture · 2023Article
- Grapevine mono- and sesquiterpenes: Genetics, metabolism, and ecophysiology.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terpenoids represent one of the major classes of natural products and serve different biological functions. In grape (Vitis vinifera), a large fraction of these compounds is present as nonvolatile terpene glycosides. We have extracted putative glycosyltransferase (GT) sequences from the grape genome database that show similarity to Arabidopsis (Arabidopsis thaliana) GTs whose encoded proteins glucosylate a diversity of terpenes. Spatial and temporal expression levels of the potential VvGT genes were determined in five different grapevine varieties. Heterologous expression and biochemical assays of candidate genes led to the identification of a UDP-glucose:monoterpenol β-d-glucosyltransferase (VvGT7). The VvGT7 gene was expressed in various tissues in accordance with monoterpenyl glucoside accumulation in grape cultivars. Twelve allelic VvGT7 genes were isolated from five cultivars, and their encoded proteins were biochemically analyzed. They varied in substrate preference and catalytic activity. Three amino acids, which corresponded to none of the determinants previously identified for other plant GTs, were found to be important for enzymatic catalysis. Site-specific mutagenesis along with the analysis of allelic proteins also revealed amino acids that impact catalytic activity and substrate tolerance. These results demonstrate that VvGT7 may contribute to the production of geranyl and neryl glucoside during grape ripening.
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Registered trials
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