ArticlePLoS genetics2014
A novel C2H2 transcription factor that regulates gliA expression interdependently with GliZ in Aspergillus fumigatus.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Gliotoxin Production and Self-Defense in Filamentous Fungi.Annual review of microbiology · 2025Review
- Progress in Gliotoxin Research.Molecules (Basel, Switzerland) · 2025Review
- Evolutionary Dynamics and Functional Bifurcation of the C2H2 Gene Family in Basidiomycota.Journal of fungi (Basel, Switzerland) · 2025Article
- The CMicrobiology spectrum · 2023Article
- Epipolythiodioxopiperazine-Based Natural Products: Building Blocks, Biosynthesis and Biological Activities.Chembiochem : a European journal of chemical biology · 2022Review
- cAMP Signalling Pathway in Biocontrol Fungi.Current issues in molecular biology · 2022Review
- Distinct Cohorts ofFrontiers in cellular and infection microbiology · 2022Article
- The Toxic Mechanism of Gliotoxins and Biosynthetic Strategies for Toxicity Prevention.International journal of molecular sciences · 2021Review
- Genomic Analysis of the MycoparasitePolish journal of microbiology · 2021Article
- Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes inFrontiers in fungal biology · 2021Article
- Regulation of Secondary Metabolism in theInternational journal of molecular sciences · 2020Review
- Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Enlightening Gliotoxin Biological System in Agriculturally RelevantFrontiers in microbiology · 2020Article
- Interaction of a Novel Zn2Cys6 Transcription Factor DcGliZ with Promoters in the Gliotoxin Biosynthetic Gene Cluster of the Deep-Sea-Derived FungusBiomolecules · 2019Article
- High Quality Draft Genome of Arogyapacha (G3 (Bethesda, Md.) · 2019Article
- Involvement of Sulfur in the Biosynthesis of Essential Metabolites in Pathogenic Fungi of Animals, ParticularlyFrontiers in microbiology · 2019Review
- Transcription Factor Repertoire of Necrotrophic Fungal PhytopathogenFrontiers in plant science · 2017Article
- Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.Eukaryotic cell · 2015Article
- Functions ofBioMed research internationalArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Secondary metabolites are produced by numerous organisms and can either be beneficial, benign, or harmful to humans. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often coordinately regulated, being almost exclusively dependent on transcription factors that are located within the clusters themselves. Gliotoxin, which is produced by a variety of Aspergillus species, Trichoderma species, and Penicillium species, exhibits immunosuppressive properties and has therefore been the subject of research for many laboratories. There have been a few proteins shown to regulate the gliotoxin cluster, most notably GliZ, a Zn2Cys6 binuclear finger transcription factor that lies within the cluster, and LaeA, a putative methyltransferase that globally regulates secondary metabolism clusters within numerous fungal species. Using a high-copy inducer screen in A. fumigatus, our lab has identified a novel C2H2 transcription factor, which plays an important role in regulating the gliotoxin biosynthetic cluster. This transcription factor, named GipA, induces gliotoxin production when present in extra copies. Furthermore, loss of gipA reduces gliotoxin production significantly. Through protein binding microarray and mutagenesis, we have identified a DNA binding site recognized by GipA that is in extremely close proximity to a potential GliZ DNA binding site in the 5' untranslated region of gliA, which encodes an efflux pump within the gliotoxin cluster. Not surprisingly, GliZ and GipA appear to work in an interdependent fashion to positively control gliA expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.