Evidence map›Paper›PMID 24784714›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2015

First-trimester maternal serum C-reactive protein as a predictor of third-trimester impaired glucose tolerance.

Erica K Berggren, Hilary A Roeder, Kim A Boggess, Kevin Moss, Steven Offenbacher, Emilia Campbell, Chad A Grotegut

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Erica K BerggrenDepartment of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA erica.berggren@gmail.com.
Hilary A RoederDepartment of Obstetrics and Gynecology, University of California, San Diego, San Diego, CA, USA.
Kim A BoggessDepartment of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kevin MossSchool of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Steven OffenbacherSchool of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Emilia CampbellDepartment of Obstetrics and Gynecology, Duke University, Durham, NC, USA.
Chad A GrotegutDepartment of Obstetrics and Gynecology, Duke University, Durham, NC, USA.
University of North Carolina at Chapel Hill · USDuke University · USThomas Jefferson University · USUniversity of California, San Diego · US

Funding

UNC Clinical and Translational Science AwardUL1TR000083 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUNGE, MARSCHALL S. · 2012 to 2013
$11.6M
NCATS NIH HHS UL1 TR000083
6 · The paper itself

Abstract

objectiveWe evaluated whether first-trimester high-sensitivity C-reactive protein (hsCRP), a suggested marker of pregnancy-associated hyperglycemia, predicts third-trimester impaired glucose tolerance (IGT) in a secondary analysis of a prospective cohort of nondiabetic singletons enrolled at <26 weeks gestation. STUDY

designWe measured the association between hsCRP collected at <14 weeks among women classified as IGT (gestational diabetes screening results, 135 to <200 mg/dL) and those among normoglycemic women. Multivariable modeling estimated the association between log hsCRP and IGT, adjusted for maternal body mass index (BMI).

resultsAmong 300 women, 13% (39 of 300) had IGT. The hsCRP was positively associated with glucose (P = .005). Compared with normoglycemic women, women with IGT had higher log hsCRP (0.87 ± 0.66 vs 0.67 ± 0.60, P = .04), but the association was not significant in adjusted models (adjusted odds ratio 1.20, 95% confidence interval 0.65-2.21). The hsCRP did not predict third-trimester IGT in this analysis when BMI is considered.

conclusionEarly identification of women at risk of IGT remains a priority, but the contribution of maternal BMI appears greater than hsCRP.

Indexed as

AdultBiomarkersBlood GlucoseBody Mass IndexChi-Square DistributionC-Reactive ProteinCross-Sectional StudiesDiabetes, GestationalFemaleHumansLinear ModelsLogistic ModelsMultivariate AnalysisOdds RatioPregnancyPregnancy Trimester, FirstBiomarkersBlood GlucoseC-Reactive Proteinearly pregnancy predictorshigh-sensitivity C-reactive proteinimpaired glucose tolerancematernal serum markers

Identifiers

PMID24784714
PMCPMC4527417
OpenAlexW2025008771

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.