ArticlePlant physiology2014
PHYTOCHROME AND FLOWERING TIME1/MEDIATOR25 Regulates Lateral Root Formation via Auxin Signaling in Arabidopsis.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Integrated Phylogenomics and Expression Profiling of the MED Gene Family inPlants (Basel, Switzerland) · 2026Article
- The role of mediator subunit MED7 in Arabidopsis development.Frontiers in plant science · 2025Article
- Photoperiodic and lighting treatments for flowering control and its genetic regulation in sugarcane breeding.Heliyon · 2024Review
- Loss-of-function ofPlant signaling & behavior · 2023Article
- Transcriptomic and Hormone Analyses Provide Insight into the Regulation of Axillary Bud Outgrowth ofCurrent issues in molecular biology · 2023Article
- MEDIATOR SUBUNIT17 is required for transcriptional optimization of root system architecture in Arabidopsis.Plant physiology · 2023Article
- Phosphate bacterial solubilization: A key rhizosphere driving force enabling higher P use efficiency and crop productivity.Journal of advanced research · 2022Review
- Repression by theeLife · 2021Article
- Review
- Functional Analysis ofFrontiers in plant science · 2021Article
- Phosphate Solubilizing Rhizobacteria Could Have a Stronger Influence on Wheat Root Traits and Aboveground Physiology Than Rhizosphere P Solubilization.Frontiers in plant science · 2020Article
- Transcriptome Analysis of FourG3 (Bethesda, Md.) · 2018Article
- The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.Plant molecular biology · 2017Article
- Validation of QTL mapping and transcriptome profiling for identification of candidate genes associated with nitrogen stress tolerance in sorghum.BMC plant biology · 2017Article
- The Multitalented MEDIATOR25.Frontiers in plant science · 2017Review
- Auxin-dependent compositional change in Mediator in ARF7- and ARF19-mediated transcription.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- An Integrated Genomic Strategy Delineates Candidate Mediator Genes Regulating Grain Size and Weight in Rice.Scientific reports · 2016Article
- Tissue-specific regulation of flowering by photoreceptors.Cellular and molecular life sciences : CMLS · 2016Review
- How and why do root apices sense light under the soil surface?Frontiers in plant science · 2015Review
- Importance of Mediator complex in the regulation and integration of diverse signaling pathways in plants.Frontiers in plant science · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root system architecture is a major determinant of water and nutrient acquisition as well as stress tolerance in plants. The Mediator complex is a conserved multiprotein complex that acts as a universal adaptor between transcription factors and the RNA polymerase II. In this article, we characterize possible roles of the MEDIATOR8 (MED8) and MED25 subunits of the plant Mediator complex in the regulation of root system architecture in Arabidopsis (Arabidopsis thaliana). We found that loss-of-function mutations in PHYTOCHROME AND FLOWERING TIME1 (PFT1)/MED25 increase primary and lateral root growth as well as lateral and adventitious root formation. In contrast, PFT1/MED25 overexpression reduces these responses, suggesting that PFT1/MED25 is an important element of meristematic cell proliferation and cell size control in both lateral and primary roots. PFT1/MED25 negatively regulates auxin transport and response gene expression in most parts of the plant, as evidenced by increased and decreased expression of the auxin-related reporters PIN-FORMED1 (PIN1)::PIN1::GFP (for green fluorescent protein), DR5:GFP, DR5:uidA, and BA3:uidA in pft1-2 mutants and in 35S:PFT1 seedlings, respectively. No alterations in endogenous auxin levels could be found in pft1-2 mutants or in 35S:PFT1-overexpressing seedlings. However, detailed analyses of DR5:GFP and DR5:uidA activity in wild-type, pft1-2, and 35S:PFT1 seedlings in response to indole-3-acetic acid, naphthaleneacetic acid, and the polar auxin transport inhibitor 1-N-naphthylphthalamic acid indicated that PFT1/MED25 principally regulates auxin transport and response. These results provide compelling evidence for a new role for PFT1/MED25 as an important transcriptional regulator of root system architecture through auxin-related mechanisms in Arabidopsis.
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Registered trials
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