ArticleBioMed research international2014
Inflammatory reaction as determinant of foreign body reaction is an early and susceptible event after mesh implantation.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Polypropylene and polyvinylidene fluoride transobturator slings for the treatment of female stress urinary incontinence: 1-Year outcomes from a multicentre randomized trial.Neurourology and urodynamics · 2021Trial
- Advances in Innovative Surgical Implant Manufacturing for Hernia Repair and Soft Tissue Reconstruction.Bioengineering (Basel, Switzerland) · 2025Review
- Acute inflammation triggered by two lightweight hernia meshes: a comparative in vitro and retrospective cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Biosynthesis of Bacterial Cellulose by Extended Cultivation with Multiple Removal of BC Pellicles.Polymers · 2021Article
- Use of polyvinylidene fluoride in treatment of female stress urinary incontinence: Efficacy and safety of midurethral slings: 24-month follow-up results.Turkish journal of urology · 2021Article
- Comparison of Surgisis, Vypro II and TiMesh in contaminated and clean field.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Laparoscopy for the Treatment of Congenital Hernia: Use of Surgical Meshes and Mesenchymal Stem Cells in a Clinically Relevant Animal Model.Frontiers in pharmacology · 2020Article
- Tissue reaction to urogynecologic meshes: effect of steroid soaking in two different mesh models.International urogynecology journal · 2016Article
- Mesh implants: An overview of crucial mesh parameters.World journal of gastrointestinal surgery · 2015Article
- [Complications associated with plastic meshes and slings. A situation like in the US?].Der Urologe. Ausg. A · 2015Article
- Coating of mesh grafts for prolapse and urinary incontinence repair with autologous plasma: exploration stage of a surgical innovation.BioMed research international · 2014Article
- Effect of platelet-rich plasma on polypropylene meshes implanted in the rabbit vagina: histological analysis.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Histological response to platelet-rich plasma added to polypropylene mesh implemented in rabbits.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model. MATERIALS AND
methodsThree different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months.
resultsMacrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min.
conclusionThe local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.
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