ArticleEuropean thyroid journal2012
Thyroid hormone replacement therapy: three 'simple' questions, complex answers.
Article in European thyroid journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Age-related variation in thyroid function - a narrative review highlighting important implications for research and clinical practice.Thyroid research · 2023Review
- Persisting symptoms in patients with Hashimoto's disease despite normal thyroid hormone levels: Does thyroid autoimmunity play a role? A systematic review.Journal of translational autoimmunity · 2021Review
- Physiological Role and Use of Thyroid Hormone Metabolites - Potential Utility in COVID-19 Patients.Frontiers in endocrinology · 2021Review
- The diagnosis and management of central hypothyroidism in 2018.Endocrine connections · 2019Review
- Combination Thyroid Hormone Replacement; Knowns and Unknowns.Frontiers in endocrinology · 2019Review
- Pediatric Hypothyroidism: Diagnosis and Treatment.Paediatric drugs · 2017Review
- Maturation in Serum Thyroid Function Parameters Over Childhood and Puberty: Results of a Longitudinal Study.The Journal of clinical endocrinology and metabolism · 2017Article
- The History and Future of Treatment of Hypothyroidism.Annals of internal medicine · 2016Article
- Scope and limitations of iodothyronine deiodinases in hypothyroidism.Nature reviews. Endocrinology · 2015Review
- Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.The Journal of clinical endocrinology and metabolism · 2015Article
- Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.The Journal of clinical investigation · 2015Article
- Paradigm shifts in thyroid hormone replacement therapies for hypothyroidism.Nature reviews. Endocrinology · 2014Review
- The role of thyroid hormone and brown adipose tissue in energy homoeostasis.The lancet. Diabetes & endocrinology · 2013Review
- Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.Biochimica et biophysica acta · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Current guidelines recommend that hypothyroid patients should be treated with levothyroxine, which in the vast majority of the cases leads to resolution of the symptoms and normalization of serum free T4 (FT4), T3 and TSH levels. However, a small group of hypothyroid patients remain symptomatic for neurocognitive dysfunction despite normal serum FT4 and TSH, which could be explained by localized brain hypothyroidism. More than half of the T3 in the brain is produced locally via the action of the type II deiodinase (D2) and variability/defects in this pathway could explain the residual symptoms. If this rationale is correct, adding liothyronine to the replacement therapy could prove beneficial. However, with a few exceptions, several clinical trials failed to identify any beneficial effects of combined therapy. More recently, the results of a large clinical trial revealed a better neurocognitive outcome with combined therapy only in hypothyroid patients carrying a polymorphism in the DIO2 gene. This obviously needs to be confirmed by other groups but it is tempting to speculate that combined levothyroxine and liothyronine has a place in the treatment of hypothyroidism, for some.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.