ArticleFrontiers in genetics2014
Why network approach can promote a new way of thinking in biology.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Is Cancer Reversible? Rethinking Carcinogenesis Models-A New Epistemological Tool.Biomolecules · 2023Review
- Albertson (Frontiers in chemistry · 2023Article
- The shift from quantitative to qualitative thinking-problems and prospects as viewed from Husserl's and Hegel's philosophy.Frontiers in psychology · 2023Article
- Network Physiology of Exercise: Beyond Molecular and Omics Perspectives.Sports medicine - open · 2022Article
- Networks of Networks: An Essay on Multi-Level Biological Organization.Frontiers in genetics · 2021Review
- (Hyper)graph Kernels over Simplicial Complexes.Entropy (Basel, Switzerland) · 2020Article
- Modelling and Recognition of Protein Contact Networks by Multiple Kernel Learning and Dissimilarity Representations.Entropy (Basel, Switzerland) · 2020Article
- What Differentiates Poor- and Good-Outcome Psychotherapy? A Statistical-Mechanics-Inspired Approach to Psychotherapy Research, Part Two: Network Analyses.Frontiers in psychology · 2020Article
- Co-emergence and Collapse: The Mesoscopic Approach for Conceptualizing and Investigating the Functional Integration of Organisms.Frontiers in physiology · 2019Article
- Modeling complexity: cognitive constraints and computational model-building in integrative systems biology.History and philosophy of the life sciences · 2018Article
- Competing Mechanisms of Stress-Assisted Diffusivity and Stretch-Activated Currents in Cardiac Electromechanics.Frontiers in physiology · 2018Article
- An Emergence Framework of Carcinogenesis.Frontiers in oncology · 2017Article
- CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition.Birth defects research. Part A, Clinical and molecular teratology · 2015Article
- CentiServer: A Comprehensive Resource, Web-Based Application and R Package for Centrality Analysis.PloS one · 2015Article
- Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.Molecular biology international · 2015Review
- Comparative transcriptomics and metabolomics in a rhesus macaque drug administration study.Frontiers in cell and developmental biology · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work deals with the particular nature of network-based approach in biology. We will comment about the shift from the consideration of the molecular layer as the definitive place where causative process start to the elucidation of the among elements (at any level of biological organization they are located) interaction network as the main goal of scientific explanation. This shift comes from the intrinsic nature of networks where the properties of a specific node are determined by its position in the entire network (top-down explanation) while the global network characteristics emerge from the nodes wiring pattern (bottom-up explanation). This promotes a "middle-out" paradigm formally identical to the time honored chemical thought holding big promises in the study of biological regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.