Evidence map›Paper›PMID 24782863›Full record

ReviewFrontiers in immunology2014

Organizing MHC Class II Presentation.

David R Fooksman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. CD70 recruitment to the immunological synapse is dependent on CD20 in B cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. PLGA nanoparticles as an efficient carrier inFrontiers in immunology · 2025
    Article
  6. Article
  7. BAP31 Knockout in Macrophages Affects CD4International journal of molecular sciences · 2023
    Article
  8. Review
  9. A novelFrontiers in microbiology · 2023
    Article
  10. Nano vaccines forFrontiers in immunology · 2022
    Article
  11. Nano DNA Vaccine EncodingPharmaceutics · 2021
    Article
  12. Hypoparathyroidism: State of the Art on Cell and Tissue Therapies.International journal of molecular sciences · 2021
    Review
  13. IL-17A Secreted by Th17 Cells Is Essential for the Host againstJournal of microbiology and biotechnology · 2021
    Article
  14. Article
  15. DNA origami demonstrate the unique stimulatory power of single pMHCs as T cell antigens.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Immunotherapy in gastrointestinal cancers.Journal of gastrointestinal oncology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David R FooksmanDepartment of Pathology, Albert Einstein College of Medicine , Bronx, NY , USA.
Albert Einstein College of Medicine · US

Funding

Cellular dynamics in germinal centers during vaccinationR01AI072529 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2007 to 2016
$4.3M
NIAID NIH HHS R01 AI072529
6 · The paper itself

Abstract

Major histocompatibility complex (MHC) class II molecules are ligands for CD4(+) T cells and are critical for initiating the adaptive immune response. This review is focused on what is currently known about MHC class II organization at the plasma membrane of antigen presenting cells and how this affects antigen presentation to T cells. The organization and diffusion of class II molecules have been measured by a variety of biochemical and microscopic techniques. Membrane lipids and other proteins have been implicated in MHC class II organization and function. However, when compared with the organization of MHC class I or TCR complexes, much less is known about MHC class II. Since clustering of T cell receptors occurs during activation, the organization of MHC molecules prior to recognition and during synapse formation may be critical for antigen presentation.

Indexed as

antigen presentationclusteringdiffusionfluorescenceMHC class IImicroscopy

Identifiers

PMID24782863
PMCPMC3989578
OpenAlexW2116379983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.