ReviewFrontiers in immunology2014
The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity.Genes & development · 2024Article
- The Pleiotropy ofInternational journal of molecular sciences · 2022Review
- ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration.The EMBO journal · 2022Article
- A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses.Journal of cell science · 2022Article
- Activated B Cells and Plasma Cells Are Resistant to Radiation Therapy.International journal of radiation oncology, biology, physics · 2022Article
- Tcf1 and Lef1 provide constant supervision to mature CD8Nature communications · 2021Article
- Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Article
- Review
- Identification of novel, clonally stable, somatic mutations targeting transcription factors PAX5 and NKX2-3, the epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell chronic lymphocytic leukemia harboring a t(14;18)(q32;q21).Cold Spring Harbor molecular case studies · 2021Article
- Role of Tet2 in Regulating Adaptive and Innate Immunity.Frontiers in cell and developmental biology · 2021Review
- Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.Nature immunology · 2020Article
- Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.Nature communications · 2020Article
- Cellular signaling and epigenetic regulation of gene expression in leukemia.Advances in biological regulation · 2020Review
- Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity.Leukemia · 2019Article
- The E3 ubiquitin ligase Itch is required for B-cell development.Scientific reports · 2019Article
- Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.Frontiers in immunology · 2019Review
- BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis.Nature communications · 2018Article
- Comprehensive profiling of transcriptional networks specific for lactogenic differentiation of HC11 mammary epithelial stem-like cells.Scientific reports · 2018Article
- Regulation of the Development and Function of B Cells by ZBTB Transcription Factors.Frontiers in immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All mature blood cells derive from hematopoietic stem cells through gradual restriction of their cell fate potential and acquisition of specialized functions. Lineage specification and cell commitment require the establishment of specific transcriptional programs involving the activation of lineage-specific genes and the repression of lineage-inappropriate genes. This process requires the concerted action of transcription factors (TFs) and epigenetic modifying enzymes. Within the hematopoietic system, B lymphopoiesis is one of the most-studied differentiation programs. Loss of function studies allowed the identification of many TFs and epigenetic modifiers required for B cell development. The usage of systematic analytical techniques such as transcriptome determination, genome-wide mapping of TF binding and epigenetic modifications, and mass spectrometry analyses, allowed to gain a systemic description of the intricate networks that guide B cell development. However, the precise mechanisms governing the interaction between TFs and chromatin are still unclear. Generally, chromatin structure can be remodeled by some TFs but in turn can also regulate (i.e., prevent or promote) the binding of other TFs. This conundrum leads to the crucial questions of who is on first, when, and how. We review here the current knowledge about TF networks and epigenetic regulation during hematopoiesis, with an emphasis on B cell development, and discuss in particular the current models about the interplay between chromatin and TFs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.