ReviewFrontiers in microbiology2014
Protective role of salt in catalysis and maintaining structure of halophilic proteins against denaturation.
Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 125 citations in OpenAlex.
- Isolation of a lipase-producing strain from yuncheng salt lake and enhancement of lipase activity via UV mutagenesis.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Nanopore-Based Profiling of PEGylation in Nucleic Acid Therapeutics.Journal of the American Chemical Society · 2026Article
- Biochemical characterization of chitinolytic Bacillus isolates from a hypersaline wetland and their biopriming potential for improving wheat germination under salinity stress.BMC plant biology · 2026Article
- Antioxidative and chaperone-like activities of a bacterioruberin-rich extract: An innovative approach to protect the skin proteome.International journal of cosmetic science · 2026Article
- Evaluation ofVeterinary and animal science · 2026Article
- Xylan Degradation in the Halotolerant BacteriumJournal of agricultural and food chemistry · 2025Article
- Engineering PHL7 for improved poly(ethylene terephthalate) depolymerization via rational design and directed evolution.Chem catalysis · 2025Article
- The salty tango of brine composition and UV photochemistry effects on Halobacterium salinarum cell envelope biosignature preservation.Communications biology · 2025Article
- Ayu: a machine intelligence tool for identification of extracellular proteins in the marine secretome.Nature communications · 2025Article
- Pharmaceutical applications of halophilic enzymes.Heliyon · 2025Review
- Halophilic and halotolerant fungi across diverse climates: a comparative study of Polish and Italian soil ecosystems.Frontiers in microbiology · 2025Article
- Understanding the Impact of Salt Stress on Plant Pathogens Through Phenotypic and Transcriptomic Analysis.Plants (Basel, Switzerland) · 2025Article
- Influence of Salinity on the Extracellular Enzymatic Activities of Marine Pelagic Fungi.Journal of fungi (Basel, Switzerland) · 2024Article
- Functional characterisation of a new halotolerant seawater active glycoside hydrolase family 6 cellobiohydrolase from a salt marsh.Scientific reports · 2024Article
- A Salt Bridge and Disulfide Bond within the Lassa Virus Fusion Domain Are Required for the Initiation of Membrane Fusion.ACS omega · 2024Article
- Synthesis, Optimization, and Characterization of Cellulase Enzyme Obtained from ThermotolerantJournal of microbiology and biotechnology · 2024Article
- Structural modulation of insulin by hydrophobic and hydrophilic molecules.RSC advances · 2023Article
- An Accessible Method to Improve the Stability and Reusability of Porcine Pancreatic α-Amylase via Immobilization in Gellan-Based Hydrogel Particles Obtained by Ionic Cross-Linking with MgMolecules (Basel, Switzerland) · 2023Article
- Optimization, partial purification, and characterization of a novel high molecular weight alkaline protease produced by Halobacillus sp. HAL1 using fish wastes as a substrate.Journal, genetic engineering & biotechnology · 2023Article
- Optimizing a therapeutic humanized follicle-stimulating hormone-blocking antibody formulation by protein thermal shift assay.Annals of the New York Academy of Sciences · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Search for new industrial enzymes having novel properties continues to be a desirable pursuit in enzyme research. The halophilic organisms inhabiting under saline/ hypersaline conditions are considered as promising source of useful enzymes. Their enzymes are structurally adapted to perform efficient catalysis under saline environment wherein n0n-halophilic enzymes often lose their structure and activity. Haloenzymes have been documented to be polyextremophilic and withstand high temperature, pH, organic solvents, and chaotropic agents. However, this stability is modulated by salt. Although vast amount of information have been generated on salt mediated protection and structure function relationship in halophilic proteins, their clear understanding and correct perspective still remain incoherent. Furthermore, understanding their protein architecture may give better clue for engineering stable enzymes which can withstand harsh industrial conditions. The article encompasses the current level of understanding about haloadaptations and analyzes structural basis of their enzyme stability against classical denaturants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.