ArticleFrontiers in microbiology2014
Metal resistance or tolerance? Acidophiles confront high metal loads via both abiotic and biotic mechanisms.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Investigating the effects of synbiotics, postbiotics and bacilli in the modulation of gut microbiota and the survival of Litopenaeus vannamei challenged with Vibrio parahaemolyticus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments.Nature communications · 2025Article
- Reactive sulfur species mediated persulfidation cascade regulation mechanism of novel transcription factor SscRAc in extremophile Acidithiobacillus caldus under extreme copper stress.Nucleic acids research · 2025Article
- Microbial diversity, metabolic properties, and biotechnological prospects of acid-sulfate soils.World journal of microbiology & biotechnology · 2025Review
- The outer membrane inApplied and environmental microbiology · 2025Article
- Acidophilic sulphate-reducing bacteria: Diversity, ecophysiology, and applications.Environmental microbiology reports · 2024Review
- Investigating the Effect of Bacilli and Lactic Acid Bacteria on Water Quality, Growth, Survival, Immune Response, and Intestinal Microbiota of CulturedAnimals : an open access journal from MDPI · 2024Article
- The Thioredoxin Fold Protein (TFP2) from Extreme AcidophilicInternational journal of molecular sciences · 2024Article
- Microbial community structure in an uranium-rich acid mine drainage site: implication for the biogeochemical release of uranium.Frontiers in microbiology · 2024Article
- Five copper homeostasis gene clusters encode the Cu-efflux resistome of the highly copper-tolerantPeerJ · 2023Article
- Chemical and Microbial Leaching of Valuable Metals from PCBs and Tantalum Capacitors of Spent Mobile Phones.International journal of environmental research and public health · 2022Article
- Microbial diversity in extreme environments.Nature reviews. Microbiology · 2022Review
- The Intestinal Bacterial Community and Functional Potential ofMicroorganisms · 2021Article
- Forced Biomineralization: A Review.Biomimetics (Basel, Switzerland) · 2021Review
- RNA transcript response by an Acidithiobacillus spp. mixed culture reveals adaptations to growth on arsenopyrite.Extremophiles : life under extreme conditions · 2021Article
- Chromium (VI) Inhibition of Low pH Bioleaching of Limonitic Nickel-Cobalt Ore.Frontiers in microbiology · 2021Article
- Metagenomic and Metatranscriptomic Study of Microbial Metal Resistance in an Acidic Pit Lake.Microorganisms · 2020Article
- Understanding Stress Response to High-Arsenic Gold-Bearing Sulfide Concentrate in Extremely Metal-Resistant AcidophileMicroorganisms · 2020Article
- Acid Experimental Evolution of the HaloarchaeonFrontiers in microbiology · 2020Article
- Diversity and functional profile of bacterial communities at Lancaster acid mine drainage dam, South Africa as revealed by 16S rRNA gene high-throughput sequencing analysis.Extremophiles : life under extreme conditions · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All metals are toxic at high concentrations and consequently their intracellular concentrations must be regulated. Extremely acidophilic microorganisms have an optimum growth of pH <3 and proliferate in natural and anthropogenic low pH environments. Some acidophiles are involved in the catalysis of sulfide mineral dissolution, resulting in high concentrations of metals in solution. Acidophiles are often described as highly metal resistant via mechanisms such as multiple and/or more efficient active resistance systems than are present in neutrophiles. However, this is not the case for all acidophiles and we contend that their growth in high metal concentrations is partially due to an intrinsic tolerance as a consequence of the environment in which they live. In this perspective, we highlight metal tolerance via complexation of free metals by sulfate ions and passive tolerance to metal influx via an internal positive cytoplasmic transmembrane potential. These tolerance mechanisms have been largely ignored in past studies of acidophile growth in the presence of metals and should be taken into account.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.