ReviewFrontiers in psychiatry2014
Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention.
Review in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Supervised, Vigorous Intensity Exercise Intervention for Depressed Female Smokers: A Pilot Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Trial
- The effects of repetitive transcranial magnetic stimulation in obese females with binge eating disorder: a protocol for a double-blinded, randomized, sham-controlled trial.BMC psychiatry · 2015Trial
- Machine-learning detection of stress severity expressed on a continuous scale using acoustic, verbal, visual, and physiological data: lessons learned.Frontiers in psychiatry · 2025Article
- Affective reactivity to daily stressors and immune cell gene expression in the MIDUS study.Brain, behavior, and immunity · 2024Article
- Examination of proinflammatory activity as a moderator of the relation between momentary interpersonal stress and suicidal ideation.Suicide & life-threatening behavior · 2023Article
- Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Longitudinal association of allostatic load with depressive symptoms among urban adults: Healthy Aging in Neighborhoods of Diversity across the Life Span study.Psychoneuroendocrinology · 2023Article
- Usability, Feasibility, and Effect of a Biocueing Intervention in Addition to a Moderated Digital Social Therapy-Platform in Young People With Emerging Mental Health Problems: A Mixed-Method Approach.Frontiers in psychiatry · 2022Article
- Article
- Demographic and Clinical Characteristics, Including Subsyndromal Symptoms Across Bipolar-Spectrum Disorders in Adolescents.Journal of child and adolescent psychopharmacology · 2020Article
- Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder.Scientific reports · 2019Article
- The Intersection of Sex Differences, Tobacco Use, and Inflammation: Implications for Psychiatric Disorders.Current psychiatry reports · 2018Review
- The Staging of Major Mood Disorders: Clinical and Neurobiological Correlates.Psychiatry investigation · 2018Article
- Favorable Impact on Stress-Related Behaviors by Modulating Plasma Butyrylcholinesterase.Cellular and molecular neurobiology · 2018Review
- Integrated transcriptome and methylome analysis in youth at high risk for bipolar disorder: a preliminary analysis.Translational psychiatry · 2017Article
- Feasibility of investigating differential proteomic expression in depression: implications for biomarker development in mood disorders.Translational psychiatry · 2015Article
- A potential role for the acid-sensing T cell death associated gene-8 (TDAG8) receptor in depression-like behavior.Physiology & behavior · 2015Article
- Dysbiotic drift: mental health, environmental grey space, and microbiota.Journal of physiological anthropology · 2015Review
- Telomeres, early-life stress and mental illness.Advances in psychosomatic medicine · 2015Review
- The Use of Cannabis as a Predictor of Early Onset of Bipolar Disorder and Suicide Attempts.Neural plasticity · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mood disorder prodrome is conceptualized as a symptomatic, but not yet clinically diagnosable stage of an affective disorder. Although a growing area, more focused research is needed in the pediatric population to better characterize psychopathological symptoms and biological markers that can reliably identify this very early stage in the evolution of mood disorder pathology. Such information will facilitate early prevention and intervention, which has the potential to affect a person's disease course. This review focuses on the prodromal characteristics, risk factors, and neurobiological mechanisms of mood disorders. In particular, we consider the influence of early-life stress, inflammation, and allostatic load in mediating neural mechanisms of neuroprogression. These inherently modifiable factors have known neuroadaptive and neurodegenerative implications, and consequently may provide useful biomarker targets. Identification of these factors early in the course of the disease will accordingly allow for the introduction of early interventions which augment an individual's capacity for psychological resilience through maintenance of synaptic integrity and cellular resilience. A targeted and complementary approach to boosting both psychological and physiological resilience simultaneously during the prodromal stage of mood disorder pathology has the greatest promise for optimizing the neurodevelopmental potential of those individuals at risk of disabling mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.