ReviewFrontiers in pharmacology2014
Neuronal localization of the 5-HT2 receptor family in the amygdaloid complex.
Review in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects.Translational psychiatry · 2017Trial
- Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing neurons of the lateral and basolateral amygdalar nuclei.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Resilience and Brain Changes in Long-Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition.Journal of magnetic resonance imaging : JMRI · 2025Article
- Loss of SPRED3 Causes Primary Hypothyroidism and Alters Thyroidal Expression of Autophagy Regulators LC3, p62, and ATG5 in Mice.International journal of molecular sciences · 2025Article
- Cannabinoid Receptors in the Horse Lateral Nucleus of the Amygdala: A Potential Target for Ameliorating Pain Perception, Stress and Anxiety in Horses.International journal of molecular sciences · 2025Article
- Focal pharmacological manipulation of serotonin signaling in the amygdala does not alter social behavior.Psychopharmacology · 2025Article
- The amygdaloid body of the family Delphinidae: a morphological study of its central nucleus through calbindin-D28k.Frontiers in neuroanatomy · 2024Article
- Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics.Molecular psychiatry · 2023Review
- Mini-review: The neurobiology of treating substance use disorders with classical psychedelics.Frontiers in neuroscience · 2023Review
- PtNPs/PEDOT:PSS-Modified Microelectrode Arrays Reveal Electrophysiological Activities of Different Neurons in Medial Amygdala of Mice Under Innate Fear.Frontiers in neuroscience · 2022Article
- Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.Frontiers in physiology · 2022Article
- Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal-amygdala 5-HTEuropean archives of psychiatry and clinical neuroscience · 2021Article
- The dorsal arcopallium of chicks displays the expression of orthologs of mammalian fear related serotonin receptor subfamily genes.Scientific reports · 2020Article
- Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HTNeuropharmacology · 2020Article
- Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients With Depression.Frontiers in pharmacology · 2019Article
- The evolutionary old forebrain as site of action to develop new psychotropic drugs.Journal of psychopharmacology (Oxford, England) · 2018Review
- Heterodimers of serotonin receptor subtypes 2 are driven by 5-HTThe Journal of biological chemistry · 2017Article
- 5-HTThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Association of Polymorphisms of Serotonin Transporter (5HTTLPR) and 5-HT2C Receptor Genes with Criminal Behavior in Russian Criminal Offenders.Neuropsychobiology · 2017Article
- Psychedelics.Pharmacological reviews · 2016Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
The amygdaloid complex (or amygdala), a heterogeneous structure located in the medial portion of the temporal lobe, is composed of deep, superficial, and "remaining" nuclei. This structure is involved in the generation of emotional behavior, in the formation of emotional memories and in the modulation of the consolidation of explicit memories for emotionally arousing events. The serotoninergic fibers originating in the dorsal and medial raphe nuclei are critically involved in amygdalar functions. Serotonin (5-hydroxytryptamine, 5-HT) regulates amygdalar activity through the activation of the 5-HT2 receptor family, which includes three receptor subtypes: 5-HT2A, 5-HT2B, and 5-HT2C. The distribution and the functional activity of the 5-HT2 receptor family has been studied more extensively than that of the 5-HT2A receptor subtypes, especially in the deep nuclei. In these nuclei, the 5-HT2A receptor is expressed on both pyramidal and non-pyramidal neurons, and could play a critical role in the formation of emotional memories. However, the exact role of the 5-HT2A receptor subtypes, as well as that of the 5-HT2B and 5-HT2C receptor subtypes, in the modulation of the amygdalar microcircuits requires additional study. The present review reports data concerning the distribution and the functional roles of the 5-HT2 receptor family in the amygdala.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.