Routine lumbar puncture for the early diagnosis of Alzheimer's disease. Is it safe?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

1. Biomarkers for the diagnosis of Alzheimer's disease, dementia Lewy body, frontotemporal dementia and vascular dementia.General psychiatry · 2019
   Pooled it
2. Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers.Journal of Alzheimer's disease : JAD · 2025
   Article
3. Mapping disparities in access to lecanemab in Georgia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
   Article
4. Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
   Review
5. Charting the Next Road Map for CSF Biomarkers in Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
   Review
6. Brain Health Indicators Following Acute Neuro-Exergaming: Biomarker and Cognition in Mild Cognitive Impairment (MCI) after Pedal-n-Play (iPACES).Brain sciences · 2023
   Article
7. Eigenbehaviour as an Indicator of Cognitive Abilities.Sensors (Basel, Switzerland) · 2022
   Article
8. State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
   Review
9. Physiological separation of Alzheimer's disease and Alzheimer's disease with significant levels of cerebrovascular symptomology and healthy controls.Medical & biological engineering & computing · 2021
   Article
10. 2020 update on the clinical validity of cerebrospinal fluid amyloid, tau, and phospho-tau as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.European journal of nuclear medicine and molecular imaging · 2021
    Review
11. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease.Neurobiology of aging · 2020
    Article
12. Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease.Scientific reports · 2020
    Article
13. Feasibility and safety of lumbar puncture in the Parkinson's disease research participants: Parkinson's Progression Marker Initiative (PPMI).Parkinsonism & related disorders · 2019
    Observational
14. Fear and Uncertainty Do Not Influence Reported Willingness to Undergo Lumbar Punctures in a U.S. Multi-Cultural Cohort.Frontiers in aging neuroscience · 2017
    Article
15. Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.Journal of Alzheimer's disease : JAD · 2017
    Article
16. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy.Journal of Alzheimer's disease : JAD · 2016
    Article
17. Biomarkers in neurodegenerative disorders: translating research into clinical practice.Frontiers in aging neuroscience · 2014
    Article
18. Safety and tolerability of lumbar puncture for the evaluation of Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article

Corrections and comments

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Authors and funding

1 author at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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