ArticleFrontiers in neuroengineering2014
Bio-inspired hybrid microelectrodes: a hybrid solution to improve long-term performance of chronic intracortical implants.
Article in Frontiers in neuroengineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Integrating living biomaterials into neuroelectronic systems.Biomedical engineering letters · 2026Review
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Bio-inspired electronics: Soft, biohybrid, and "living" neural interfaces.Nature communications · 2025Review
- The Future of Biohybrid Regenerative Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Tissue engineering strategies for spiral ganglion neuron protection and regeneration.Journal of nanobiotechnology · 2024Review
- Biohybrid neural interfaces: improving the biological integration of neural implants.Chemical communications (Cambridge, England) · 2023Review
- Implantable intracortical microelectrodes: reviewing the present with a focus on the future.Microsystems & nanoengineering · 2023Review
- Fabrication of Soft Tissue Scaffold-Mimicked Microelectrode Arrays Using Enzyme-Mediated Transfer Printing.Micromachines · 2021Article
- The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Improving Deep Brain Stimulation Electrode PerformanceFrontiers in neuroscience · 2021Article
- Neurohybrid Memristive CMOS-Integrated Systems for Biosensors and Neuroprosthetics.Frontiers in neuroscience · 2020Article
- Bioactive Neuroelectronic Interfaces.Frontiers in neuroscience · 2019Review
- Focal, remote-controlled, chronic chemical modulation of brain microstructures.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Potential for thermal damage to the blood-brain barrier during craniotomy: implications for intracortical recording microelectrodes.Journal of neural engineering · 2018Review
- Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry.Advanced functional materials · 2018Article
- Miniaturized neural system for chronic, local intracerebral drug delivery.Science translational medicine · 2018Article
- Biomimetic extracellular matrix coatings improve the chronic biocompatibility of microfabricated subdural microelectrode arrays.PloS one · 2018Article
- Microfabricated intracortical extracellular matrix-microelectrodes for improving neural interfaces.Microsystems & nanoengineering · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of implants that allow chronic electrical stimulation and recording in the brain of human patients is currently limited by a series of events that cause the deterioration over time of both the electrode surface and the surrounding tissue. The main reason of failure is the tissue inflammatory reaction that eventually causes neuronal loss and glial encapsulation, resulting in a progressive increase of the electrode-electrolyte impedance. Here, we describe a new method to create bio-inspired electrodes to mimic the mechanical properties and biological composition of the host tissue. This combination has a great potential to increase the implant lifetime by reducing tissue reaction and improving electrical coupling. Our method implies coating the electrode with reprogrammed neural or glial cells encapsulated within a hydrogel layer. We chose fibrin as a hydrogel and primary hippocampal neurons or astrocytes from rat brain as cellular layer. We demonstrate that fibrin coating is highly biocompatible, forms uniform coatings of controllable thickness, does not alter the electrochemical properties of the microelectrode and allows good quality recordings. Moreover, it reduces the amount of host reactive astrocytes - over time - compared to a bare wire and is fully reabsorbed by the surrounding tissue within 7 days after implantation, avoiding the common problem of hydrogels swelling. Both astrocytes and neurons could be successfully grown onto the electrode surface within the fibrin hydrogel without altering the electrochemical properties of the microelectrode. This bio-hybrid device has therefore a good potential to improve the electrical integration at the neuron-electrode interface and support the long-term success of neural prostheses.
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