ArticleFrontiers in human neuroscience2014
Association of COMT and COMT-DRD2 interaction with creative potential.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Dopaminergic and Noradrenergic Contributions to Divergent and Convergent Creativity Task Performance, a Systematic Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Creativity as emulation: the cultural basis of creative cognition.Frontiers in psychology · 2024Article
- Blending oxytocin and dopamine with everyday creativity.Scientific reports · 2021Article
- Cortical thickness mediates the relationship between DRD2 C957T polymorphism and executive function across the adult lifespan.Brain structure & function · 2021Article
- Paternal indifference and neglect in early life and creativity: Exploring the moderating role of TPH1 genotype and offspring gender.PloS one · 2020Article
- No association ofPeerJ · 2019Article
- The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms.Frontiers in neural circuits · 2019Review
- Article
- Interaction between COMT rs5993883 and second generation antipsychotics is linked to decreases in verbal cognition and cognitive control in bipolar disorder.BMC psychology · 2016Article
- The Association ofFrontiers in psychology · 2016Article
- Dopamine and the Creative Mind: Individual Differences in Creativity Are Predicted by Interactions between Dopamine Genes DAT and COMT.PloS one · 2016Article
- Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms.Frontiers in psychology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence suggest that genes involved in dopamine (DA) transmission may contribute to creativity. Among these genes, the catechol-O-methyltransferase gene (COMT) and the dopamine D2 receptor gene (DRD2) are the most promising candidates. Our previous study has revealed evidence for the involvement of DRD2 in creative potential. The present study extended our previous study by systematically exploring the association of COMT with creative potential as well as the interaction between COMT and DRD2. Twelve single nucleotide polymorphisms (SNPs) covering COMT were genotyped in 543 healthy Chinese college students whose creative potentials were assessed by divergent thinking tests. Single SNP analysis showed that rs174697 was nominally associated with verbal originality, two SNPs (rs737865 and rs5993883) were nominally associated with figural fluency, and two SNPs (rs737865 and rs4680) were nominally associated with figural originality. Haplotype analysis showed that, the TCT and CCT haplotype (rs737865-rs174675-rs5993882) were nominally associated with figural originality, and the TATGCAG and CGCGGGA haplotype (rs4646312-rs6269-rs4633-rs6267-rs4818-rs4680-rs769224) were nominally associated with figural originality and verbal flexibility, respectively. However, none of these nominal findings survived correction for multiple testing. Gene-gene interaction analysis identified one significant four-way interaction of rs174675 (COMT), rs174697 (COMT), rs1076560 (DRD2), and rs4436578 (DRD2) on verbal fluency, one significant four-way interaction of rs174675 (COMT), rs4818 (COMT), rs1076560 (DRD2), and rs4648317 (DRD2) on verbal flexibility, and one significant three-way interaction of rs5993883 (COMT), rs4648319 (DRD2), and rs4648317 (DRD2) on figural flexibility. In conclusion, the present study provides nominal evidence for the involvement of COMT in creative potential and suggests that DA related genes may act in coordination to contribute to creativity.
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