ArticleFrontiers in cellular neuroscience2014
Kir3 channel ontogeny - the role of Gβγ subunits in channel assembly and trafficking.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The Gβ1 and Gβ3 Subunits Differentially Regulate Rat Vascular Kv7 Channels.Frontiers in physiology · 2019Article
- PPIP5K1 Suppresses Etoposide-triggered Apoptosis.Journal of molecular signaling · 2016Article
- The truth in complexes: perspectives on ion channel signaling nexuses in the nervous system.Frontiers in cellular neuroscience · 2014Article
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Authors and funding
6 authors.
Funding
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Abstract
The role of Gβγ subunits in Kir3 channel gating is well characterized. Here, we have studied the role of Gβγ dimers during their initial contact with Kir3 channels, prior to their insertion into the plasma membrane. We show that distinct Gβγ subunits play an important role in orchestrating and fine-tuning parts of the Kir3 channel life cycle. Gβ1γ2, apart from its role in channel opening that it shares with other Gβγ subunit combinations, may play a unique role in protecting maturing channels from degradation as they transit to the cell surface. Taken together, our data suggest that Gβ1γ2 prolongs the lifetime of the Kir3.1/Kir3.2 heterotetramer, although further studies would be required to shed more light on these early Gβγ effects on Kir3 maturation and trafficking.
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