Evidence map›Paper›PMID 24782594›Full record

ReviewMediators of inflammation2014

Autoantibodies to posttranslational modifications in rheumatoid arthritis.

Agata N Burska, Laura Hunt, Marjorie Boissinot, Rocky Strollo, Brent J Ryan, Ed Vital, Ahuva Nissim, Paul G Winyard, Paul Emery, Frederique Ponchel

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Biosimilarity and Interchangeability: Principles and Evidence: A Systematic Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Agata N BurskaLeeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, UK.
Laura HuntLeeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, UK.
Marjorie BoissinotLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK.ORCID 0000-0002-5241-2520
Rocky StrolloCentre for Biochemical Pharmacology Research Unit, William Harvey Research Institute, Barts and London, Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, London EC1M 6BQ, UK.
Brent J RyanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, Oxford OX1 3QX, UK.
Ed VitalLeeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, UK.
Ahuva NissimCentre for Biochemical Pharmacology Research Unit, William Harvey Research Institute, Barts and London, Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, London EC1M 6BQ, UK.
Paul G WinyardUniversity of Exeter Medical School, St. Luke's Campus, Exeter, Devon EX1 2LU, UK.
Paul EmeryLeeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, UK.
Frederique PonchelLeeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, UK.
University of Leeds · GBUniversity of London · GBUniversity of Exeter · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/J002747/1Versus Arthritis 18475
6 · The paper itself

Abstract

Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs). Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA). The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational modifications (PTM) relevant to RA have since been described. Such PTM introduce neoepitopes in proteins that can generate novel autoantibody specificities. The recent recognition of these novel specificities in RA provides a unique opportunity to understand human B-cell development in vivo. In this paper, we will review the three of the main classes of PTMs already associated with RA: citrullination, carbamylation, and oxidation. With the advancement of research methodologies it should be expected that other autoantibodies against PTM proteins could be discovered in patients with autoimmune diseases. Many of such autoantibodies may provide significant biomarker potential.

Indexed as

Protein Processing, Post-TranslationalAnimalsAntigensAntioxidantsArthritis, RheumatoidAutoantibodiesBiomarkersB-LymphocytesCitrullineHumansInflammationOxygenReactive Oxygen SpeciesAntigensAntioxidantsAutoantibodiesBiomarkersCitrullineOxygenReactive Oxygen Species

Identifiers

PMID24782594
PMCPMC3981057
OpenAlexW1967330974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.